Tedisamil

Base Information

Chemical Name:Tedisamil
CAS No.:90961-53-8
Molecular Formula:C₁₉H₃₂N₂
Molecular Weight:288.476
Hs Code.:
UNII:A5VAY2U3R8
DSSTox Substance ID:DTXSID30238334
Nikkaji Number:J346.050I
Wikipedia:Tedisamil
Wikidata:Q3982536
NCI Thesaurus Code:C72585
Pharos Ligand ID:S2RJPL6J9W7S,S2RY6KT7Y74Q
Metabolomics Workbench ID:149672
ChEMBL ID:CHEMBL2111110,CHEMBL113461
Mol file:90961-53-8.mol

Synonyms:3,7-di-(cyclopropylmethyl)-9,9-tetramethylene-3,7-diazabicyclo(3.3.1)nonane;KC 8857;KC-8857;tedisamil

Suppliers and Price of Tedisamil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TEDISAMIL 95.00%
5MG
$ 496.93

Total 6 raw suppliers

Chemical Property of Tedisamil

Chemical Property:

Vapor Pressure:9.61E-06mmHg at 25°C
Boiling Point:372.5°Cat760mmHg
Flash Point:162.6°C
PSA：6.48000
Density:1.09g/cm³
LogP:3.10620
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:288.256549029
Heavy Atom Count:21
Complexity:348

Purity/Quality:

99% ^*data from raw suppliers

TEDISAMIL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC2(C1)C3CN(CC2CN(C3)CC4CC4)CC5CC5
Recent EU Clinical Trials:Controlled, Parallel Design Study to Evaluate the Efficacy and Safety of Intravenous Tedisamil Sesquifumarate in the Rapid Conversion to Normal Sinus Rhythm in Female Subjects with Recent Onset Atrial Fibrillation or Flutter
Uses Antiarrhythmic agent (Ktchannel blocker).

Technology Process of Tedisamil

There total 3 articles about Tedisamil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: C₁₉H₂₄N₂O₄

: 90961-53-8
tedisamil

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; toluene; at 120 ℃;
DOI:10.1021/jm970120q

Reference yield:

: 42940-56-7
7,9-dioxo-8-azaspiro[4.5]decane-6,10-dicarbonitrile

: 90961-53-8
tedisamil

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / 60percent aq. H₂SO₄ / 120 - 140 °C

2: 1.) K₂CO₃ / 1.) DMF, reflux, 1 h, 2.) DMF, reflux, 3 h

3: 79 percent / LiAlH₄ / tetrahydrofuran; toluene / 120 °C

With lithium aluminium tetrahydride; sulfuric acid; potassium carbonate; In tetrahydrofuran; toluene;
DOI:10.1021/jm970120q

Reference yield:

: 90961-77-6
spiro[cyclopentane-1,9'-(3,7-diaza-bicyclo[3.3.1]nonane)]-2',4',6',8'-tetraone

: 90961-53-8
tedisamil

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) K₂CO₃ / 1.) DMF, reflux, 1 h, 2.) DMF, reflux, 3 h

2: 79 percent / LiAlH₄ / tetrahydrofuran; toluene / 120 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; toluene;
DOI:10.1021/jm970120q