4-Isothiazolecarbonitrile, 5-[(2,4-dichlorophenyl)amino]-2,3-dihydro-3-oxo-

Base Information

Chemical Name:4-Isothiazolecarbonitrile, 5-[(2,4-dichlorophenyl)amino]-2,3-dihydro-3-oxo-
CAS No.:663958-23-4
Molecular Formula:C₁₀H₅Cl₂N₃OS
Molecular Weight:286.141
Hs Code.:

Synonyms:5-(2,4-Dichloro-phenylamino)-3-hydroxy-isothiazole-4-carbonitrile;

Suppliers and Price of 4-Isothiazolecarbonitrile, 5-[(2,4-dichlorophenyl)amino]-2,3-dihydro-3-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Isothiazolecarbonitrile, 5-[(2,4-dichlorophenyl)amino]-2,3-dihydro-3-oxo-

Chemical Property:

PSA：97.18000
LogP:3.84378

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of 4-Isothiazolecarbonitrile, 5-[(2,4-dichlorophenyl)amino]-2,3-dihydro-3-oxo-

There total 2 articles about 4-Isothiazolecarbonitrile, 5-[(2,4-dichlorophenyl)amino]-2,3-dihydro-3-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6590-96-1
2, 4-dichlorophenyl isothiocyanate

: 663958-23-4
5-(2,4-dichlorophenylamino)-3-hydroxyisothiazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / dimethylformamide / 16 h / 20 °C

2: bromine / ethyl acetate / 1 h / 20 °C

With potassium hydroxide; bromine; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.019

Reference yield:

: 554-00-7,51908-09-9
2,4-Dichloroaniline

: 663958-23-4
5-(2,4-dichlorophenylamino)-3-hydroxyisothiazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: CHCl₃ / 2 h / 20 °C

2: KOH / dimethylformamide / 20 °C

3: Br₂ / ethyl acetate / 2.5 h / 20 °C

With potassium hydroxide; bromine; In chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.10.002