3-(3-methoxyphenyl)-1-methyl-1H-pyrrole-2,5-dione

Base Information

• Chemical Name: 3-(3-methoxyphenyl)-1-methyl-1H-pyrrole-2,5-dione
• CAS No.: 66504-57-2
• Molecular Formula: C12H11NO3
• Molecular Weight: 217.224
• ChEMBL ID: CHEMBL446119
• DSSTox Substance ID: DTXSID80512419
• Wikidata: Q82371637

Synonyms:66504-57-2;3-(3-methoxyphenyl)-1-methyl-1H-pyrrole-2,5-dione;CHEMBL446119;SCHEMBL10993386;DTXSID80512419;DBZVFURVMWKTSK-UHFFFAOYSA-N;2-(m-methoxyphenyl)-N-methylmaleimide

Chemical Property of 3-(3-methoxyphenyl)-1-methyl-1H-pyrrole-2,5-dione

Chemical Property:

• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 217.07389321
• Heavy Atom Count: 16
• Complexity: 348

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1C(=O)C=C(C1=O)C2=CC(=CC=C2)OC

Technology Process of 3-(3-methoxyphenyl)-1-methyl-1H-pyrrole-2,5-dione

There total 4 articles about 3-(3-methoxyphenyl)-1-methyl-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H12ClNO3 (1159989-34-0) → 2-(3-methoxyphenyl)-N-methylmaleimide (66504-57-2)

Guidance literature:

With 2,6-dimethylpyridine; In isopropyl alcohol; at 100 ℃; for 0.25h;

DOI:10.1016/j.bmc.2009.03.005

Reference yield:

N-methylmaleimide (930-88-1) + m-Anisidine (536-90-3,918666-97-4) → 2-(3-methoxyphenyl)-N-methylmaleimide (66504-57-2)

Guidance literature:

With 2,6-dimethylpyridine; hydrogenchloride; sodium acetate; sodium nitrite; Yield given. Multistep reaction;

DOI:10.1021/jm00371a012

Reference yield:

N-methylmaleimide (930-88-1) + 3-methoxy-benzenediazonium; chloride (19183-05-2) → 2-(3-methoxyphenyl)-N-methylmaleimide (66504-57-2)

Guidance literature:

With 2,6-dimethylpyridine; copper dichloride; Multistep reaction; 1) aq. acetone, 2) heating;

DOI:10.1039/c39800000314

upstream raw materials:

N-methylmaleimide

3-methoxy-benzenediazonium; chloride

m-Anisidine

C₁₂H₁₂ClNO₃

Downstream raw materials:

4,4-dimethoxy-1-(3-methoxyphenyl)-N-methyl-1,2-cyclobutanedicarboximide

bis(3-methoxyphenyl)-N,N'-dimethyl-1,2,3,4-cyclobutane-tetracarboxylic 1,2:3,4-diimide

5-(3-methoxyphenyl)-3,5',5'-trimethylspiro<3-azabicyclo<3.2.0>heptane-6,2'-<1,3>dioxane>

6,6-dimethoxy-5-(3-methoxyphenyl)-3-methyl-3-azabicyclo<3.2.0>heptane

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