2,6-Bis(2-hydroxy-benzylidene)cyclohexanone

Base Information

• Chemical Name: 2,6-Bis(2-hydroxy-benzylidene)cyclohexanone
• CAS No.: 66508-99-4
• Molecular Formula: C20H18O3
• Molecular Weight: 306.361
• DSSTox Substance ID: DTXSID401237999
• Mol file: 66508-99-4.mol

Synonyms:SCHEMBL3581744;DTXSID401237999;2,6-bis(2-hydroxy-benzylidene)cyclohexanone;2,6-Bis[(2-hydroxyphenyl)methylene]cyclohexanone;66508-99-4

Chemical Property of 2,6-Bis(2-hydroxy-benzylidene)cyclohexanone

Chemical Property:

• XLogP3: 4.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 306.125594432
• Heavy Atom Count: 23
• Complexity: 449

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(=CC2=CC=CC=C2O)C(=O)C(=CC3=CC=CC=C3O)C1

Technology Process of 2,6-Bis(2-hydroxy-benzylidene)cyclohexanone

There total 2 articles about 2,6-Bis(2-hydroxy-benzylidene)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + salicylaldehyde (90-02-8) → 2,6-bis((E)-2-hydroxybenzylidine)cyclohexanone (66508-99-4)

Guidance literature:

With aminosulfonic acid; at 80 ℃; for 3h; neat (no solvent);

DOI:10.1016/j.cclet.2011.03.015

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + salicylaldehyde (90-02-8) → 2,6-bis((E)-2-hydroxybenzylidine)cyclohexanone (66508-99-4) + 3,3′-trimethylenedibenzospiropyran (7130-08-7,132356-79-7,132512-62-0)

Guidance literature:

With sodium hydroxide; In ethanol; water; Inert atmosphere;

DOI:10.1016/j.molstruc.2021.130598

Reference yield:

2,6-bis((E)-2-hydroxybenzylidine)cyclohexanone (66508-99-4) → C20H17O2(1+)

Guidance literature:

at 25 ℃; for 29h; pH=< 1; Acidic conditions;

DOI:10.1016/j.jphotochem.2014.03.008

upstream raw materials:

cyclohexanone

salicylaldehyde