4-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxylic Acid

Base Information

• Chemical Name: 4-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxylic Acid
• CAS No.: 666721-06-8
• Molecular Formula: C12H7F3O3S
• Molecular Weight: 288.247
• DSSTox Substance ID: DTXSID90471088
• Wikidata: Q82299497
• Mol file: 666721-06-8.mol

Synonyms:4-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxylic Acid;666721-06-8;SCHEMBL6374857;DTXSID90471088;4-[4-(Trifluoromethoxy)phenyl]-2-thiophenecarboxylic acid, AldrichCPR

Chemical Property of 4-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxylic Acid

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 288.00679974
• Heavy Atom Count: 19
• Complexity: 327

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CSC(=C2)C(=O)O)OC(F)(F)F

Technology Process of 4-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxylic Acid

There total 3 articles about 4-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.4%

4-[4-(trifluoromethoxy)phenyl]thiophene-2-carbaldehyde (666721-05-7) → 4-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxylic acid (666721-06-8)

Guidance literature:

With sodium hydroxide; silver nitrate; In ethanol; water; at 40 ℃; for 2h;

Reference yield:

4-bromo-thiophene-2-carboxylic acid (16694-18-1) + 4-trifluoromethoxyphenylboronic acid (139301-27-2) → 4-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxylic acid (666721-06-8)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 80 ℃;

DOI:10.1016/j.bmcl.2005.05.079

Reference yield:

4-Bromothiophen-2-aldehyde (18791-75-8) → 4-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxylic acid (666721-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: AgNO₃; aq. NaOH / ethanol / 40 °C

2: Pd(PPh₃)4; aq. K₃PO₄ / 1,2-dimethoxy-ethane / 80 °C

With sodium hydroxide; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver nitrate; In 1,2-dimethoxyethane; ethanol; 2: Suzuki coupling;

DOI:10.1016/j.bmcl.2005.05.079

upstream raw materials:

4-bromo-thiophene-2-carboxylic acid

4-trifluoromethoxyphenylboronic acid

4-Bromothiophen-2-aldehyde

4-[4-(trifluoromethoxy)phenyl]thiophene-2-carbaldehyde

Downstream raw materials:

4-[4-(trifluoromnethoxy)phenyl]thiophene-2-carbonyl chloride

(R)-{[4-(4-trifluoromthoxyphenyl)thien-2-yl]carboxamido}(phenyl)propanoic acid

trans-4-({[4-(4-trifluoromethoxyphenyl)thien-2-yl]-carboxamido}methyl)cyclohexanecarboxylic acid