Linagliptin Impurity D

Base Information

Chemical Name:Linagliptin Impurity D
CAS No.:666816-91-7
Molecular Formula:C20H28N6O4
Molecular Weight:416.47400
Hs Code.:
Mol file:666816-91-7.mol

Synonyms:3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine;Linagliptin Impurity D;3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butyloxycarbonylamino)-piperidin-1-yl]-3,7-dihydro-1H-purine-2,6-dione;3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butyloxycarbonylamino)-piperidin-1-yl]-xanthine;3-methyl-7-(but-2-yn-1-yl)-8-[(R)-3-(tert-butyloxycarbonylamino)-piperidin-1-yl]-xanthine;3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butyloxycarbonyl-amino)-piperidin-1-yl]-xanthine;Linagliptin Impurity 21;3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-tert-butoxycarbonylaminopiperidin-1-yl)-xanthine;3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butyloxycarbonylamino)-piperidin-1-yl]-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine;Linagliptin impurity;Carbamic acid,[(3R)-1-[7-(2-butynyl)-2,3,6,7-tetrahydro-3-methyl-2,6-dioxo-1H-purin-8-yl]-3-piperidinyl]-, 1,1-dimethylethyl ester;Linagliptin;

Suppliers and Price of Linagliptin Impurity D

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tertbutyloxycarbonylamino)piperidin-1-yl]-xanthine
100mg
$ 375.00

Total 16 raw suppliers

Chemical Property of Linagliptin Impurity D

Chemical Property:

PKA:9.38±0.70(Predicted)
PSA：114.25000
Density:1.32±0.1 g/cm3(Predicted)
LogP:1.39600

Purity/Quality:

97% ^*data from raw suppliers

3-Methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tertbutyloxycarbonylamino)piperidin-1-yl]-xanthine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 3-Methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tertbutyloxycarbonylamino)piperidin-1-yl]-xanthine is a useful synthetic compound.

Technology Process of Linagliptin Impurity D

There total 3 articles about Linagliptin Impurity D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

: 666816-98-4
8-bromo-7-(but2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6–dione

: 666816-91-7
3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butoxycarbonylamino)piperidin-1-yl]xanthine

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 114 ℃; for 6h;

Reference yield:

: 93703-24-3
3-methyl-8-bromoxanthine

: 666816-91-7
3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butoxycarbonylamino)piperidin-1-yl]xanthine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; potassium iodide; methyl tributylammonium chloride / tetrahydrofuran / Inert atmosphere; Reflux

2: potassium iodide; potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate / Isopropyl acetate / Reflux

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; N-ethyl-N,N-diisopropylamine; methyl tributylammonium chloride; potassium iodide; In tetrahydrofuran; Isopropyl acetate;