1-[6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl]-1-hydroxyurea

Base Information

• Chemical Name: 1-[6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl]-1-hydroxyurea
• CAS No.: 139148-95-1
• Molecular Formula: C₁₈H₂₀N₂O₃
• Molecular Weight: 312.368

Synonyms:N-Hydroxy-N-(1,2,3,4-tetrahydro-6-(phenylmethoxy)-1-naphthalenyl)urea;SK&CTK4C1649;(+/-)-N-hydroxy-N-[1,2,3,4-tetrahydro-6-(benzyloxy)-1-naphthalenyl]urea;

Chemical Property of 1-[6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl]-1-hydroxyurea

Chemical Property:

• Vapor Pressure: 2.79E-12mmHg at 25°C
• Boiling Point: 535.1°Cat760mmHg
• Flash Point: 277.4°C
• PSA: 76.78000
• Density: 1.3g/cm³
• LogP: 3.92670

Purity/Quality:

N-HYDROXY-N-[1,2,3,4-TETRAHYDRO-6-(BENZYLOXY)-1-NAPHTHALENYL]UREA 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl]-1-hydroxyurea

There total 2 articles about 1-[6-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl]-1-hydroxyurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Benzyloxy-3,4-dihydro-2H-naphthalen-1-one oxime (66361-92-0) → (+/-)-N-hydroxy-N-[1,2,3,4-tetrahydro-6-(benzyloxy)-1-naphthalenyl]urea (139148-95-1,139149-52-3,139149-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1: BH₃*Py, HCl / Ambient temperature

2: tetrahydrofuran / 55 °C

With hydrogenchloride; borane pyridine; In tetrahydrofuran;

DOI:10.1021/jm960271d

Reference yield:

trimethylsilyl isocyanate (1118-02-1) + N-(6-Benzyloxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-hydroxylamine (139149-02-3) → (+/-)-N-hydroxy-N-[1,2,3,4-tetrahydro-6-(benzyloxy)-1-naphthalenyl]urea (139148-95-1,139149-52-3,139149-53-4)

Guidance literature:

In tetrahydrofuran; at 55 ℃; Yield given;

DOI:10.1021/jm960271d

Reference yield:

(S)-4-benzyloxazolidin-2-one-3-carbonyl chloride (139149-49-8) + (+/-)-N-hydroxy-N-[1,2,3,4-tetrahydro-6-(benzyloxy)-1-naphthalenyl]urea (139148-95-1,139149-52-3,139149-53-4) → C29H29N3O6 + C29H29N3O6

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)73875-5

upstream raw materials:

trimethylsilyl isocyanate

N-(6-Benzyloxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-hydroxylamine

6-Benzyloxy-3,4-dihydro-2H-naphthalen-1-one oxime

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