Chemical Property of (Z)-3-(acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one
Chemical Property:
- Boiling Point:534.4±60.0 °C(Predicted)
- PKA:-2.57±0.20(Predicted)
- PSA：58.97000
- Density:1.50±0.1 g/cm3(Predicted)
- LogP:4.52580
- Storage Temp.:Desiccate at +4°C
- Solubility.:DMSO: soluble16mg/mL
- XLogP3:4.6
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:4
- Exact Mass:395.983525
- Heavy Atom Count:25
- Complexity:571
- Purity/Quality:
-
99%, *data from raw suppliers
LDN 57444 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:N
- Statements:
50/53
- Safety Statements:
60-61
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
- Isomeric SMILES:CC(=O)O/N=C\1/C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
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Description
The ubiquitin C-terminal hydrolase L1 (UCH-L1) is a member of a family of de-ubiquitinating enzymes that can generate free ubiquitin from ubiquitin precursors via its ubiquitin ligase activity. By associating with free ubiquitin, it also prevents its degradation. Neuronal UCH-L1 has been linked to Parkinson’s disease, the development of tumors, and neuropathic pain. LDN-57444 is an inhibitor of UCH-L1 activity (IC50 = 0.88, Ki = 0.4 μM) that demonstrates selectivity for UCH-L1 compared to UCH-L3 (IC50 = 25 μM). Loss of UCH-L1 activity causes cell death through the apoptosis pathway due to an impaired ubiquitin-proteasome pathway. LDN-57444-induced reduction of free ubiquitin has been shown to create dramatic alterations in synaptic structure and function, increasing spine size while decreasing spine density in hippocampal neurons.
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Uses
LDN 57444 is an inhibitor of UCH-L1, an enzyme expressed by certain lung tumor-derived cell lines, suggesting that this enzyme plays a role in tumor progression.
