(2S)-2-((S)-Phenyl{[2-(trifluoromethyl)phenyl]thio}methyl)morpholine

Base Information

Chemical Name:(2S)-2-((S)-Phenyl{[2-(trifluoromethyl)phenyl]thio}methyl)morpholine
CAS No.:668470-56-2
Molecular Formula:C18H18F3NOS
Molecular Weight:353.408
Hs Code.:
DSSTox Substance ID:DTXSID50430914
Wikidata:Q82244661

Synonyms:(2S)-2-((S)-Phenyl{[2-(trifluoromethyl)phenyl]thio}methyl)morpholine;668470-56-2;SCHEMBL4653871;DTXSID50430914

Suppliers and Price of (2S)-2-((S)-Phenyl{[2-(trifluoromethyl)phenyl]thio}methyl)morpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of (2S)-2-((S)-Phenyl{[2-(trifluoromethyl)phenyl]thio}methyl)morpholine

Chemical Property:

XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:353.10611986
Heavy Atom Count:24
Complexity:387

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COC(CN1)C(C2=CC=CC=C2)SC3=CC=CC=C3C(F)(F)F
Isomeric SMILES:C1CO[C@@H](CN1)[C@H](C2=CC=CC=C2)SC3=CC=CC=C3C(F)(F)F

Technology Process of (2S)-2-((S)-Phenyl{[2-(trifluoromethyl)phenyl]thio}methyl)morpholine

There total 3 articles about (2S)-2-((S)-Phenyl{[2-(trifluoromethyl)phenyl]thio}methyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 668470-89-1
(S)-phenyl[(2S)-4-(phenylmethyl)morpholin-2-yl]methyl-(2-trifluoromethyl)phenyl sulfide

: 668470-56-2
(2S)-2-((S)-[phenyl]{[2-trifluoromethylphenyl]thio}methyl)morpholine

Guidance literature:: (S)-phenyl[(2S)-4-(phenylmethyl)morpholin-2-yl]methyl-(2-trifluoromethyl)phenyl sulfide; With polymer supported Hünig's base; carbonochloridic acid 1-chloro-ethyl ester; In dichloromethane; at 40 ℃;

In methanol; at 60 ℃; for 1.5 - 4h;

With sodium hydroxide; In water; ethyl acetate;

Reference yield: 43.0%

: (2R)-4-[(1R)-1-phenylethyl]-2-((R)-phenyl{[2-(trifluoromethyl)phenyl]thio}methyl)morpholine

: 668470-56-2
(2S)-2-((S)-[phenyl]{[2-trifluoromethylphenyl]thio}methyl)morpholine

Guidance literature:: (2R)-4-[(1R)-1-phenylethyl]-2-((R)-phenyl{[2-(trifluoromethyl)phenyl]thio}methyl)morpholine; With polymer supported Hünig's base; carbonochloridic acid 1-chloro-ethyl ester; In dichloromethane; at 20 ℃;

In methanol; at 70 ℃; for 2h;