5-Bromothiophene-2-sulfonamide

Base Information

• Chemical Name: 5-Bromothiophene-2-sulfonamide
• CAS No.: 53595-65-6
• Molecular Formula: C4H4BrNO2S2
• Molecular Weight: 242.117
• Hs Code.: 29350090
• European Community (EC) Number: 611-018-9
• DSSTox Substance ID: DTXSID20361302
• Nikkaji Number: J1.906.873K
• Wikidata: Q72513074
• ChEMBL ID: CHEMBL453143
• Mol file: 53595-65-6.mol

Synonyms:5-Bromothiophene-2-sulfonamide;53595-65-6;5-Bromo-2-thiophenesulfonamide;5-bromo-thiophene-2-sulfonic acid amide;2-thiophenesulfonamide, 5-bromo-;5-Bromothiophene-2-sulfonic acid amide;MFCD00067990;5-bromothiophene-2-sulphonamide;2-bromo thiophene-5-sulfonamide;Maybridge1_004885;5-bromothien-2-ylsulfonamide;SCHEMBL625352;CHEMBL453143;5-bromo-thiophene-2-sulfonamide;2-Bromo Thiophene-5-Sulfomamide;5-bromothiophene-2-sulfonylamine;HMS555G01;DTXSID20361302;CL1309;STL136488;5-Bromothiophene-2-sulfonamide, 97%;AKOS000115245;AC-7516;CS-W002311;FS-1090;AM100917;SY007636;A7796;B2793;BB 0242861;EU-0099362;FT-0620177;EN300-01203;J-517218;Z45415650;F0918-7881

Chemical Property of 5-Bromothiophene-2-sulfonamide

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 3.56E-06mmHg at 25°C
• Melting Point: 134-142 °C
• Refractive Index: 1.646
• Boiling Point: 386.4 °C at 760 mmHg
• PKA: 9.75±0.60(Predicted)
• Flash Point: 187.5 °C
• PSA: 96.78000
• Density: 1.951 g/cm³
• LogP: 2.93910
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: soluble in Methanol
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 240.88668
• Heavy Atom Count: 10
• Complexity: 210

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromothiophene-2-sulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=C(SC(=C1)Br)S(=O)(=O)N
• Uses: 5-Bromothiophene-2-sulfonamide may be used to synthesize:5-(phenylthio)thiophene-2-sulfonamide5-bromothiophene-2-sulfonyl acetamide5-arylthiophene-2-sulfonylacetamide derivativesIt may also be used in the preparation of the following 5-arylthiophene-2-sulfonamides:5-phenylthiophene-2-sulfonamide5-(3-cyno-5-(trifluoromethyl)phenyl)thiophene-2-sulfonamide5-(3,5-bis(trifluoromethyl)phenyl)thiophene-2-sulfonamide5′-chloro-2,2′-bithiophene-5-sulfonamide 5′-methyl-2,2′-bithiophene-5-sulfonamide 5-p-tolylthiophene-2-sulfonamide5-(4-methoxyphenyl)thiophene-2-sulfonamide5-(4-chlorophenyl)thiophene-2-sulfonamide5-(3,4-dichlorophenyl)thiophene-2-sulfonamide5-(3,5-dimethylphenyl)thiophene-2-sulfonamide5-(4-chloro-3-fluorophenyl)thiophene-2-sulfonamide

Technology Process of 5-Bromothiophene-2-sulfonamide

There total 7 articles about 5-Bromothiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ 5-bromo-thiophene-2-sulfonamide (53595-65-6)

Guidance literature:

Reference yield: 96.0%

5-bromothiophene-2-sulphonic acid tert-butylamide (286932-39-6) → 5-bromo-thiophene-2-sulfonamide (53595-65-6)

Guidance literature:

With boron trichloride; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(03)01020-7

Reference yield: 95.9%

5-bromo-2-thiophenesulfonyl chloride (55854-46-1) → 5-bromo-thiophene-2-sulfonamide (53595-65-6)

Guidance literature:

With ammonium hydroxide; In 2-methyltetrahydrofuran; water; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/op800210x

upstream raw materials:

5-bromo-2-thiophenesulfonyl chloride

5-bromothiophene-2-sulphonic acid tert-butylamide

2,5-dibromothiophen

2-bromothiophene

Downstream raw materials:

4-{[5-(aminosulfonyl)-2-thienyl]thio}benzoic acid

5-[(2-chlorophenyl)thio]thiophene-2-sulfonamide

2,4-dichloro-N-[(5-bromo-2-thienyl)sulfonyl]benzenecarboxamide

5-(2-methoxyphenyl)thienyl-2-sulfonamide

Refernces

• 1、 Sang, Dayong,Dong, Bingqian,Liu, Yunfeng,Tian, Juan. "Chemoselective Cleavage of Acylsulfonamides and Sulfonamides by Aluminum Halides". . p. 3586 - 3595. Retrieved 2022/02/25.
• 2、 -. "DIPHENYL SUBSTITUTED THIOPHENE-2-AMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS ANTIMICROBIAL". Page/Page column 22; 25. . Retrieved 2019/10/01.