3-Bromo-4-methoxy-6-methyl-2-pyrone

Base Information

• Chemical Name: 3-Bromo-4-methoxy-6-methyl-2-pyrone
• CAS No.: 670-35-9
• Molecular Formula: C7H7BrO3
• Molecular Weight: 219.035
• Hs Code.: 2932999099
• Mol file: 670-35-9.mol

Synonyms:3-bromo-4-methoxy-6-methyl-pyran-2-one;2H-Pyran-2-one,3-bromo-4-methoxy-6-methyl;3-Bromo-4-methoxy-6-methyl-2-pyrone;3-Brom-4-methoxy-6-methyl-pyran-2-on;3-Bromo-4-methoxy-6-methyl-2-pyranone;3-Bromo-4-methoxy-6-methyl-2H-pyran-2-one;

Chemical Property of 3-Bromo-4-methoxy-6-methyl-2-pyrone

Chemical Property:

• PSA: 39.44000
• LogP: 1.71930

Purity/Quality:

95% ^*data from raw suppliers

2H-Pyran-2-one,3-bromo-4-methoxy-6-methyl- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-4-methoxy-6-methyl-2-pyrone

There total 3 articles about 3-Bromo-4-methoxy-6-methyl-2-pyrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-methoxy-6-methyl-2H-pyran-2-one (672-89-9) → 3-bromo-4-methoxy-6-methyl-2H-pyran-2-one (670-35-9)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; at 80 ℃; for 1h;

DOI:10.1039/c9ob00968j

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 3-bromo-6-methyl-pyran-2,4-dione (110654-20-1) → 3-bromo-4-methoxy-6-methyl-2H-pyran-2-one (670-35-9)

Guidance literature:

With diethyl ether;

DOI:10.1246/bcsj.35.1329

Reference yield:

→ 3-bromo-4-methoxy-6-methyl-2H-pyran-2-one (670-35-9)

Guidance literature:

entspr. Pyron, NBS;

DOI:10.1021/jo00830a016

upstream raw materials:

4-methoxy-6-methyl-2H-pyran-2-one

diazomethane

3-bromo-6-methyl-pyran-2,4-dione

Downstream raw materials:

4-methoxy-6-methyl-2H-pyran-2-one

Refernces

• 1、 Schieferdecker, Sebastian,Shabuer, Gulimila,Knuepfer, Uwe,Hertweck, Christian. "Clostrindolin is an antimycobacterial pyrone alkaloid from: Clostridium beijerinckii". supporting information. p. 6119 - 6121. Retrieved 2019/07/03.
• 2、 March, P. de,Moreno-Manas, M.,Pi, R.,Ripoll, I.,Sanchez-Fernando, F.. "Brominated Derivatives of 4-Hydroxy- and 4-Methoxy-6-methyl-2H-pyran-2-ones". . p. 1537 - 1542. Retrieved 2007/10/02.