1-methyl-4-(1-methyl-1H-pyrazole-4-carbonyl)-1H-pyrazole

Base Information

Chemical Name:1-methyl-4-(1-methyl-1H-pyrazole-4-carbonyl)-1H-pyrazole
CAS No.:67088-78-2
Molecular Formula:C₉H₁₀N₄O
Molecular Weight:190.205
Hs Code.:
European Community (EC) Number:820-101-0

Synonyms:1-methyl-4-(1-methyl-1H-pyrazole-4-carbonyl)-1H-pyrazole;67088-78-2;bis(1-methylpyrazol-4-yl)methanone;AKOS014529168;BS-45667;CS-0160265;FT-0724133;E74646;EN300-1697450;Z1258920714

Suppliers and Price of 1-methyl-4-(1-methyl-1H-pyrazole-4-carbonyl)-1H-pyrazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1-methyl-4-(1-methyl-1H-pyrazole-4-carbonyl)-1H-pyrazole

Chemical Property:

XLogP3:-0.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:190.08546096
Heavy Atom Count:14
Complexity:211

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=C(C=N1)C(=O)C2=CN(N=C2)C

Technology Process of 1-methyl-4-(1-methyl-1H-pyrazole-4-carbonyl)-1H-pyrazole

There total 4 articles about 1-methyl-4-(1-methyl-1H-pyrazole-4-carbonyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 39806-90-1
4-iodo-1-methyl-1H-pyrazole

: 1283120-11-5
N-methoxy-N,1-dimethyl-1H-pyrazole-4-carboxamide

: 67088-78-2
bis(1-methyl-1H-pyrazol-4-yl)methanone

Guidance literature:: 4-iodo-1-methyl-1H-pyrazole; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 1h;

N-methoxy-N,1-dimethyl-1H-pyrazole-4-carboxamide; In tetrahydrofuran; at -78 - 20 ℃; for 2h;
DOI:10.1021/ml300063m

Reference yield:

: 5952-92-1
1-methyl-1H-pyrazole-4-carboxylic acid

: 67088-78-2
bis(1-methyl-1H-pyrazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.17 h / 0 - 20 °C

2.1: potassium carbonate / dichloromethane; water / 20 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 °C

3.2: 2 h / -78 - 20 °C

With oxalyl dichloride; isopropylmagnesium chloride; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ml300063m

Reference yield:

: 79583-19-0
1-methyl-1H-pyrazole-4-carbonyl chloride

: 67088-78-2
bis(1-methyl-1H-pyrazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / dichloromethane; water / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 0 °C

2.2: 2 h / -78 - 20 °C

With isopropylmagnesium chloride; potassium carbonate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ml300063m