4-CHLOROMETHYL-5-METHYL-2-O-TOLYL-OXAZOLE

Base Information

• Chemical Name: 4-CHLOROMETHYL-5-METHYL-2-O-TOLYL-OXAZOLE
• CAS No.: 671215-81-9
• Molecular Formula: C12H12ClNO
• Molecular Weight: 221.686
• Hs Code.: 2934999090
• Mol file: 671215-81-9.mol

Synonyms:4-Chloromethyl-5-methyl-2-o-tolyl-oxazole;2-(2-methyl-phenyl)-4-chloromethyl-5-methyl-oxazole;

Chemical Property of 4-CHLOROMETHYL-5-METHYL-2-O-TOLYL-OXAZOLE

Chemical Property:

• PSA: 26.03000
• LogP: 3.69720

Purity/Quality:

97% ^*data from raw suppliers

4-(chloromethyl)-5-methyl-2-(2-methylphenyl)-1,3-oxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLOROMETHYL-5-METHYL-2-O-TOLYL-OXAZOLE

There total 3 articles about 4-CHLOROMETHYL-5-METHYL-2-O-TOLYL-OXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4,5-dimethyl-2-(o-tolyl)oxazole 3-oxide (933027-20-4) → 4-(chloromethyl)-5-methyl-2-(o-tolyl)oxazole (671215-81-9)

Guidance literature:

With trichlorophosphate; In chloroform; at 0 ℃; for 12h; pH=10; Heating / reflux;

Reference yield:

2-methylphenyl aldehyde (529-20-4) → 4-(chloromethyl)-5-methyl-2-(o-tolyl)oxazole (671215-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl; AcOH / 0 °C

2: POCl₃ / CHCl₃ / Heating

With hydrogenchloride; acetic acid; trichlorophosphate; In chloroform;

DOI:10.1016/j.bmcl.2006.05.007

Reference yield:

→ 4-(chloromethyl)-5-methyl-2-(o-tolyl)oxazole (671215-81-9)

Guidance literature:

upstream raw materials:

4,5-dimethyl-2-(o-tolyl)oxazole 3-oxide

2-methylphenyl aldehyde

Downstream raw materials:

(±)-N-(3-(3-methylpiperidin-1-yl)propyl)-1-((5-methyl-2-(o-tolyl)-oxazol-4-yl)methyl)piperidine-4-carboxamide

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