2,6-Dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarbonitrile

Base Information

• Chemical Name: 2,6-Dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarbonitrile
• CAS No.: 67438-96-4
• Molecular Formula: C15H12N4O2
• Molecular Weight: 280.286
• DSSTox Substance ID: DTXSID80384754

Synonyms:2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarbonitrile;67438-96-4;Oprea1_576134;SCHEMBL7815167;DTXSID80384754;AKOS024326516;2,6-DIMETHYL-4-(4-NITRO-PHENYL)-1,4-DIHYDRO-PYRIDINE-3,5-DICARBONITRILE

Chemical Property of 2,6-Dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarbonitrile

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 280.09602564
• Heavy Atom Count: 21
• Complexity: 577

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(C(=C(N1)C)C#N)C2=CC=C(C=C2)[N+](=O)[O-])C#N

Technology Process of 2,6-Dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarbonitrile

There total 4 articles about 2,6-Dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

3-Aminocrotononitrile (1118-61-2) + 4-nitrobenzaldehdye (555-16-8) → 1-(4-nitrophenyl)-3-oxo-1-butene-2-carbonitrile (127844-32-0) + 3-acetyl-6-methyl-2,4-di(4-nitrophenyl)-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile (127844-52-4) + 2,6-dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarbonitrile (67438-96-4)

Guidance literature:

With piperidine; acetic acid; In ethanol; Ambient temperature;

Reference yield:

4-nitrobenzaldehdye (555-16-8) → 2,6-dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarbonitrile (67438-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CH₂Cl₂ / 1 h / 0 °C

2: CH₂Cl₂ / Ambient temperature

With thionyl chloride; In dichloromethane;

DOI:10.1016/S0040-4020(01)90788-4

Reference yield:

(E)-3-aminocrotononitrile (763-33-7) + N-pyridinium chloride (140429-25-0) → 2,6-dimethyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarbonitrile (67438-96-4)

Guidance literature:

In dichloromethane; Yield given; Ambient temperature;

DOI:10.1016/S0040-4020(01)90788-4

upstream raw materials:

3-Aminocrotononitrile

4-nitrobenzaldehdye

(E)-3-aminocrotononitrile

N-pyridinium chloride

Downstream raw materials:

N-(2,4-dicyano-1,5-dimethyl-3-(4'-nitrophenyl)cyclopenta-2,4-dienyl)-2',2',2'-trifluoroacetamide

1,2,6-Trimethyl-4-(4-nitro-phenyl)-1,2-dihydro-pyridine-3,5-dicarbonitrile

2,6-Dimethyl-4-(4-nitro-phenyl)-1,2-dihydro-pyridine-3,5-dicarbonitrile

3,5-dicyano-2,6-dimethyl-4-(p-nitrophenyl)pyridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 67438-96-4 3,5-Pyridinedicarbonitrile, 1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-

Send

Send

Metric Ton KG G Pound L ML

Send

Send