1-(2-Ethoxyphenyl)-3-phenylurea

Base Information

• Chemical Name: 1-(2-Ethoxyphenyl)-3-phenylurea
• CAS No.: 4300-34-9
• Molecular Formula: C₁₅H₁₆N₂O₂
• Molecular Weight: 256.304
• NSC Number: 164411
• DSSTox Substance ID: DTXSID90304165
• Wikidata: Q82049900
• Mol file: 4300-34-9.mol

Synonyms:1-(2-ethoxyphenyl)-3-phenylurea;4300-34-9;NSC164411;Cambridge id 5402896;Oprea1_590002;DTXSID90304165;STK979714;AKOS001215737;NSC-164411;AB00084096-01;SR-01000207953;SR-01000207953-1;Z44609105

Chemical Property of 1-(2-Ethoxyphenyl)-3-phenylurea

Chemical Property:

• Vapor Pressure: 0.000375mmHg at 25°C
• Boiling Point: 317.9°C at 760 mmHg
• Flash Point: 146°C
• Density: 1.218g/cm³
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 256.121177757
• Heavy Atom Count: 19
• Complexity: 277

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1NC(=O)NC2=CC=CC=C2

Technology Process of 1-(2-Ethoxyphenyl)-3-phenylurea

There total 7 articles about 1-(2-Ethoxyphenyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenyl isothiocyanate (103-72-0) → N-(2-ethoxy-phenyl)-N'-phenyl-urea (4300-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene

2: potassium iodate; aqueous NaOH-solution

With potassium iodate; sodium hydroxide; toluene;

DOI:10.1021/ja01350a023

Reference yield:

ortho-phenitidine (94-70-2) → N-(2-ethoxy-phenyl)-N'-phenyl-urea (4300-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene

2: potassium iodate; aqueous NaOH-solution

With potassium iodate; sodium hydroxide; toluene;

DOI:10.1021/ja01350a023

Reference yield:

phenyl isocyanate (103-71-9) → N-(2-ethoxy-phenyl)-N'-phenyl-urea (4300-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: alcoholic KOH-solution

With potassium hydroxide; diethyl ether;

DOI:10.1016/S0022-5347(05)67364-8

upstream raw materials:

(2-ethoxy-phenyl)-carbamic acid ethyl ester

aniline

N-carboethoxyaniline

ortho-phenitidine