Chemical Property of Thielavin B
Chemical Property:
- Vapor Pressure:1.52E-27mmHg at 25°C
- Boiling Point:807.5°C at 760 mmHg
- Flash Point:261.1°C
- PSA：148.82000
- Density:1.276g/cm3
- LogP:5.71880
- Storage Temp.:-20°C
- XLogP3:7
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:10
- Rotatable Bond Count:9
- Exact Mass:566.21519728
- Heavy Atom Count:41
- Complexity:940
- Purity/Quality:
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98%,99%, *data from raw suppliers
Thielavin B *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC(=C(C(=C1C(=O)OC2=C(C(=C(C(=C2C)C)C(=O)OC3=C(C(=C(C(=C3C)C)C(=O)O)OC)C)OC)C)O)C)O
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Description
Thielavin B is a fungal metabolite that contains O-substituted salicylic acid. It inhibits cyclooxygenase, blocking both the conversion of arachidonic acid to Prostaglandin H2 (PGH2) and the conversion of PGH2 to PGE2 (, IC50s = 40 and 9 μM, respectively). Thielavin B also inhibits the reverse transcriptase of avian myeloblastosis virus, bacterial transglycosylases, and telomerase activity.
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Uses
Thielavin B is a fungal metabolite closely related to thielavin A but reported to have a slightly different biochemical profile. Thielavins inhibit glucose-6-phosphatase. Thielavin B is a potent inhibitor of phospholipase C, and inhibits peptidoglycan formation and prostaglandin biosynthesis. Thielavin B is a fungal metabolite of?Thielavia terricola that contains O-substituted salicylic acid. It is an inhibitor of viral reverse transcriptase and telomerase.
