Base Information
- Chemical Name:6-Hexadecynoic acid
- CAS No.:676-25-5
- Molecular Formula:C16H28O2
- Molecular Weight:
- Hs Code.:
Synonyms:
Synonyms:
85.0-99.8% *data from raw suppliers
The research focuses on the structure-activity relationship of antiestrogens, specifically phenolic analogues of 2,3-diaryl-2H-1-benzopyrans (DABP). The purpose of the study was to synthesize and evaluate these compounds for their potential as antiestrogens, with the aim of understanding the molecular origins of their partial agonist-antagonist character. The conclusions drawn from the research indicated that the incorporation of hydroxyl groups at certain positions in the benzopyran structure significantly improved receptor affinity and antagonist activity without affecting estrogen agonist activity. Notably, the monophenol 19 and the diphenol 25 emerged as potent antiestrogens, exhibiting marked antiestrogenic activity and being more effective than tamoxifen, trioxifen, and LY-117018.
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