Sembragiline

Base Information

Chemical Name:Sembragiline
CAS No.:676479-06-4
Molecular Formula:C19H19FN2O3
Molecular Weight:342.37
Hs Code.:
UNII:K3W9672PNJ
Wikidata:Q27281921
NCI Thesaurus Code:C152331
Pharos Ligand ID:HVUBXTDMT17H
ChEMBL ID:CHEMBL3707394

Synonyms:EVT 302;RG1577;RO4602522;sembragiline

Suppliers and Price of Sembragiline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Sembragiline

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:342.13797063
Heavy Atom Count:25
Complexity:479

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)NC1CC(=O)N(C1)C2=CC=C(C=C2)OCC3=CC(=CC=C3)F
Isomeric SMILES:CC(=O)N[C@H]1CC(=O)N(C1)C2=CC=C(C=C2)OCC3=CC(=CC=C3)F
Recent ClinicalTrials:A Study of RO4602522 in Participants With Moderate Severity Alzheimer Disease on Background Alzheimer Disease Therapy
Recent EU Clinical Trials:A PHASE II, MULTICENTER, RANDOMIZED, DOUBLE-BLIND,
Recent NIPH Clinical Trials:None

Technology Process of Sembragiline

There total 13 articles about Sembragiline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: (S)-3-acetylamino-N-[4-(3-fluoro-benzyloxy)-phenyl]-4-hydroxy-butyramide

: 676479-06-4
N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-pyrrolidin-3-yl]acetamide

Guidance literature:: (S)-3-acetylamino-N-[4-(3-fluoro-benzyloxy)-phenyl]-4-hydroxy-butyramide; With thionyl chloride; In toluene; at 50 - 92 ℃; for 18.75h;

With potassium tert-butylate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at -10 - 20 ℃; for 7h;