Phenol, 3-[2-(4-hydroxyphenyl)ethyl]-5-methoxy-

Base Information

• Chemical Name: Phenol, 3-[2-(4-hydroxyphenyl)ethyl]-5-methoxy-
• CAS No.: 67884-29-1
• Molecular Formula: C15H16O3
• Molecular Weight: 244.29
• DSSTox Substance ID: DTXSID30434213
• Nikkaji Number: J2.018.941J
• Wikidata: Q82248559
• Metabolomics Workbench ID: 134618
• ChEMBL ID: CHEMBL448371
• Mol file: 67884-29-1.mol

Synonyms:Phenol, 3-[2-(4-hydroxyphenyl)ethyl]-5-methoxy-;67884-29-1;5-Methoxybibenzyl-3,4'-diol;CHEMBL448371;SCHEMBL16568144;DTXSID30434213;3,4'-dihydroxy-5-methoxybibenzyl

Chemical Property of Phenol, 3-[2-(4-hydroxyphenyl)ethyl]-5-methoxy-

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 244.109944368
• Heavy Atom Count: 18
• Complexity: 236

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)O)CCC2=CC=C(C=C2)O

Technology Process of Phenol, 3-[2-(4-hydroxyphenyl)ethyl]-5-methoxy-

There total 9 articles about Phenol, 3-[2-(4-hydroxyphenyl)ethyl]-5-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-(benzyloxy)-5-methoxybenzyl)triphenylphosphonium bromide (54922-80-4) → 3,4'-dihydroxy-5-methoxybibenzyl (67884-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent

2: H₂

With hydrogen;

Reference yield:

p-benzyloxybenzaldehyde (4397-53-9) → 3,4'-dihydroxy-5-methoxybibenzyl (67884-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOEt / ethanol

2: H₂ / Pd-C / ethanol

With hydrogen; sodium ethanolate; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0031-9422(00)94310-3

Reference yield:

1-Benzyloxy-3-[(Z)-2-(4-benzyloxy-phenyl)-vinyl]-5-methoxy-benzene (68692-54-6) → 3,4'-dihydroxy-5-methoxybibenzyl (67884-29-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0031-9422(00)94310-3

upstream raw materials:

3,4'-dihydroxy-5-methoxystilbene

1-Benzyloxy-3-[(Z)-2-(4-benzyloxy-phenyl)-vinyl]-5-methoxy-benzene

1-Benzyloxy-3-[(E)-2-(4-benzyloxy-phenyl)-vinyl]-5-methoxy-benzene

(3-(benzyloxy)-5-methoxyphenyl)methanol

Downstream raw materials:

p-hydroxybibenzyl/o-cannabidiol monomethyl ether hybrid

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