1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-

Base Information

Chemical Name:1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-
CAS No.:681136-29-8
Molecular Formula:C19H19N5OS
Molecular Weight:365.459
Hs Code.:
UNII:62521S57AU
DSSTox Substance ID:DTXSID00384599
Nikkaji Number:J2.907.829G
Wikidata:Q27894028
Pharos Ligand ID:2X3SQQ8VDLG9
ChEMBL ID:CHEMBL460273
Mol file:681136-29-8.mol

Synonyms:4-(3-phenyl-(1,2,4)-thiadiazol-5-yl)piperazine-1-carboxylic acid phenylamide;JNJ-1661010

Suppliers and Price of 1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
JNJ-1661010
100mg
$ 515.00

TRC
JNJ-1661010
10mg
$ 90.00

Tocris
JNJ1661010 ≥99%(HPLC)
50
$ 626.00

Tocris
JNJ1661010 ≥99%(HPLC)
10
$ 153.00

Sigma-Aldrich
JNJ-1661010 ≥98% (HPLC)
5mg
$ 88.20

Sigma-Aldrich
JNJ-1661010 ≥98% (HPLC)
25mg
$ 319.00

Medical Isotopes, Inc.
JNJ-1661010
10 mg
$ 610.00

DC Chemicals
JNJ-1661010 >98%
250 mg
$ 800.00

DC Chemicals
JNJ-1661010 >98%
1 g
$ 1600.00

DC Chemicals
JNJ-1661010 >98%
100 mg
$ 400.00

Total 22 raw suppliers

Chemical Property of 1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-

Chemical Property:

PKA:13.94±0.70(Predicted)
PSA：89.60000
Density:1.340±0.06 g/cm3(Predicted)
LogP:3.63510
Storage Temp.:Store at +4°C
Solubility.:DMSO: ≥28mg/mL
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:365.13103142
Heavy Atom Count:26
Complexity:459

Purity/Quality:

99%, ^*data from raw suppliers

JNJ-1661010 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1C2=NC(=NS2)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4
Description JNJ-1661010 (681136-29-8) is a potent and selective FAAH inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC50 = 12 nM. 100-fold selectivity for FAAH-1 over FAAH-2. Cell permeable and active in vivo. JNJ-1661010 displays analgesic activity in various animal models.
Uses JNJ-1661010, is used to examine the contribution of endocannabinoid signaling in experimental fibrosis. In biological studies, JNJ 1661010 had shown to elevate the levels of arachidonoyl ethanolamide (AEA) in rat brains.

Technology Process of 1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-

There total 2 articles about 1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.4%