1-Benzyl-4-[4-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

Base Information

Chemical Name:1-Benzyl-4-[4-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine
CAS No.:681482-24-6
Molecular Formula:C19H18F3N
Molecular Weight:317.354
Hs Code.:
DSSTox Substance ID:DTXSID50583136
Nikkaji Number:J2.458.354F
Wikidata:Q82474653

Synonyms:681482-24-6;1-benzyl-4-[4-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine;1-BENZYL-4-[4-(TRIFLUOROMETHYL)PHENYL]-3,6-DIHYDRO-2H-PYRIDINE;1-BENZYL-4-(4-(TRIFLUOROMETHYL)PHENYL)-1,2,3,6-TETRAHYDROPYRIDINE;SCHEMBL1470365;DTXSID50583136;1-(phenylmethyl)-4-[4-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine;A836031;1-Benzyl-4-(4-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine;1-Benzyl-4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydro-pyridine;1-benzyl-4-(4-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine

Suppliers and Price of 1-Benzyl-4-[4-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-Benzyl-4-[4-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

Chemical Property:

XLogP3:5.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:317.13913406
Heavy Atom Count:23
Complexity:401

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CC=C1C2=CC=C(C=C2)C(F)(F)F)CC3=CC=CC=C3

Technology Process of 1-Benzyl-4-[4-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

There total 6 articles about 1-Benzyl-4-[4-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 936231-01-5
1-benzyl-4-(benzyldimethylsilanyl)-1,2,3,6-tetrahydro-pyridine hydrochloride

: 455-13-0
4-Iodobenzotrifluoride

: 681482-24-6
1-benzyl-4-(4-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine

Guidance literature:: With tetrabutyl ammonium fluoride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ol070241c

Reference yield: 98.0%

: 58778-51-1
1-benzyl-4-(4-(trifluoromethyl)phenyl)-piperidin-4-ol

: 681482-24-6
1-benzyl-4-(4-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine

Guidance literature:: 1-benzyl-4-(4-(trifluoromethyl)phenyl)-piperidin-4-ol; With trifluoroacetic acid; for 168h; Heating / reflux;

With ammonia; In water; at 20 ℃; for 1h; pH=9;

Reference yield: 28.0%

: 3612-20-2
1-phenylmethyl-4-piperidone

: 455-13-0
4-Iodobenzotrifluoride

: 681482-24-6
1-benzyl-4-(4-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine

Guidance literature:: 4-Iodobenzotrifluoride; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

1-phenylmethyl-4-piperidone; In tetrahydrofuran; at -78 - 20 ℃;

With hydrogenchloride; sodium hydrogencarbonate; more than 3 stages;