Propionic acid 2-(6-amino-purin-9-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Propionic acid 2-(6-amino-purin-9-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester
CAS No.:65174-99-4
Molecular Formula:C13H17N5O5
Molecular Weight:323.3046
Hs Code.:
DSSTox Substance ID:DTXSID70983750
ChEMBL ID:CHEMBL3228698

Synonyms:65174-99-4;Propionic acid 2-(6-amino-purin-9-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester;CHEMBL3228698;SCHEMBL10588023;DTXSID70983750;9-(2-O-Propanoylpentofuranosyl)-9H-purin-6-amine;[(2R,3S,4R,5R)-2-(6-aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl] propanoate

Suppliers and Price of Propionic acid 2-(6-amino-purin-9-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propionic acid 2-(6-amino-purin-9-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

Chemical Property:

Vapor Pressure:1.4E-16mmHg at 25°C
Refractive Index:1.6500 (estimate)
Boiling Point:626.9°Cat760mmHg
Flash Point:332.9°C
PSA：145.61000
Density:1.77g/cm³
LogP:-0.43790
Water Solubility.:117mg/L(37 oC)
XLogP3:0
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:5
Exact Mass:323.12296866
Heavy Atom Count:23
Complexity:441

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(=O)OC1C(C(OC1N2C=NC3=C(N=CN=C32)N)CO)O
Isomeric SMILES:CCC(=O)O[C@H]1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N)CO)O

Technology Process of Propionic acid 2-(6-amino-purin-9-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

There total 4 articles about Propionic acid 2-(6-amino-purin-9-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 87970-04-5
9-<2-O-propionyl-3,5-bis-O-(tert-butyldimethylsilyl)-β-D-arabinofuranosyl>adenine

: 65174-99-4
9-(2-O-propionyl-β-D-arabinofuranosyl)adenine

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm00369a007

Reference yield:

: 82870-42-6
9-<3,5-bis-O-(tert-butyldimethylsilyl)-β-D-arabinofuranosyl>adenine

: 65174-99-4
9-(2-O-propionyl-β-D-arabinofuranosyl)adenine

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / pyridine / 48 h / 0 - 5 °C

2: 85 percent / n-Bu₄NF, glacial AcOH / tetrahydrofuran

With pyridine; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm00369a007

Reference yield:

: 5536-17-4
arabinosyl adenine

: 65174-99-4
9-(2-O-propionyl-β-D-arabinofuranosyl)adenine

Guidance literature:: Multi-step reaction with 3 steps

1: 76.4 percent / Et₃N / dimethylformamide / 36 h / Ambient temperature

2: 88 percent / pyridine / 48 h / 0 - 5 °C

3: 85 percent / n-Bu₄NF, glacial AcOH / tetrahydrofuran

With pyridine; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00369a007