2-[4-(Piperidin-1-yl)butyl]-1H-isoindole-1,3(2H)-dione

Base Information

Chemical Name:2-[4-(Piperidin-1-yl)butyl]-1H-isoindole-1,3(2H)-dione
CAS No.:6821-01-8
Molecular Formula:C17H22N2O2
Molecular Weight:286.374
Hs Code.:
DSSTox Substance ID:DTXSID70524465
Wikidata:Q82391344

Synonyms:6821-01-8;SCHEMBL3174057;DTXSID70524465;SKQBYDFHJHJMIZ-UHFFFAOYSA-N;2-[4-(Piperidin-1-yl)butyl]-1H-isoindole-1,3(2H)-dione;2-(4-Piperidin-1-yl-butyl)-isoindole-1,3-dione;2-(4-piperidin-1-ylbutyl)-1H-isoindole-1,3(2H)-dione

Suppliers and Price of 2-[4-(Piperidin-1-yl)butyl]-1H-isoindole-1,3(2H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-[4-(Piperidin-1-yl)butyl]-1H-isoindole-1,3(2H)-dione

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:286.168127949
Heavy Atom Count:21
Complexity:366

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCN(CC1)CCCCN2C(=O)C3=CC=CC=C3C2=O

Technology Process of 2-[4-(Piperidin-1-yl)butyl]-1H-isoindole-1,3(2H)-dione

There total 1 articles about 2-[4-(Piperidin-1-yl)butyl]-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7743-29-5
[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-triphenyl-phosphonium bromide

: 6821-01-8
2-(4-(piperidin-1-yl)butyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / N,N-dimethyl-formamide / 0.25 h / 200 °C / Microwave irradiation

2: hydrogen; palladium on activated charcoal / tetrahydrofuran; methanol / 0.83 h

With palladium on activated charcoal; hydrogen; sodium methylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: |Wittig Olefination;
DOI:10.1016/j.bmcl.2013.09.052

Reference yield:

: 6821-01-8
2-(4-(piperidin-1-yl)butyl)isoindoline-1,3-dione

: 848861-40-5
4-piperidinobutylcarbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / 12 h / Heating

2: 72 percent / aq. NaOH / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; sodium hydroxide; In tetrahydrofuran;
DOI:10.1002/ardp.200400897

Reference yield:

: 6821-01-8
2-(4-(piperidin-1-yl)butyl)isoindoline-1,3-dione

: C₂₇H₄₄N₄OS

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 0.25 h / 120 °C / Microwave irradiation

2: toluene / 0.5 h / 60 °C

3: diamide; tributylphosphine / tetrahydrofuran / 16 h / 20 °C

With tributylphosphine; diamide; hydrazine hydrate; In tetrahydrofuran; ethanol; toluene;
DOI:10.1016/j.bmcl.2013.09.052