Dimethyl-7-hydroxy-2-oxoheptyl phosphonate, 95 %

Base Information

Chemical Name:Dimethyl-7-hydroxy-2-oxoheptyl phosphonate, 95 %
CAS No.:68382-89-8
Molecular Formula:C9H19O5P
Molecular Weight:238.21800
Hs Code.:
Mol file:68382-89-8.mol

Synonyms:

Suppliers and Price of Dimethyl-7-hydroxy-2-oxoheptyl phosphonate, 95 %

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 6 raw suppliers

Chemical Property of Dimethyl-7-hydroxy-2-oxoheptyl phosphonate, 95 %

Chemical Property:

PSA：82.64000
LogP:1.59410

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Dimethyl-7-hydroxy-2-oxoheptyl phosphonate, 95 %

There total 1 articles about Dimethyl-7-hydroxy-2-oxoheptyl phosphonate, 95 % which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 502-44-3,24980-41-4,80137-66-2
hexahydro-2H-oxepin-2-one

: 756-79-6
dimethyl methane phosphonate

: 68382-89-8
Dimethyl (7-hydroxy-5-oxoheptyl)phosphonate

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h; Inert atmosphere;

hexahydro-2H-oxepin-2-one; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

With oxalic acid; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.tetlet.2015.01.164

Reference yield:

: 68382-89-8
Dimethyl (7-hydroxy-5-oxoheptyl)phosphonate

: (3aR,4R,5R,6aS)-4-(E)-8-(tert-butyldimethylsilyloxy)-3-oxooct-1-enyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 2.5 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1016/j.tetlet.2015.01.164

Reference yield:

: 68382-89-8
Dimethyl (7-hydroxy-5-oxoheptyl)phosphonate

: (3aR,4R,5R,6aS)-4-((S,E)-8-(tert-butyldimethylsilyloxy)-3-hydroxyoct-1-enyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 2.5 h / 0 - 20 °C / Inert atmosphere

3.1: cerium(III) chloride heptahydrate; sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Inert atmosphere

With 1H-imidazole; sodium tetrahydroborate; cerium(III) chloride heptahydrate; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; mineral oil;
DOI:10.1016/j.tetlet.2015.01.164