1-Piperazinecarboxylic acid, 4-[3-[[7-[(4-fluorophenyl)methyl]-7,8-dihydro-9-hydroxy-5-methoxy-8-oxo -6H-pyrrolo[3,4-g]quinolin-6-yl]thio]-1-oxopropyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-[3-[[7-[(4-fluorophenyl)methyl]-7,8-dihydro-9-hydroxy-5-methoxy-8-oxo -6H-pyrrolo[3,4-g]quinolin-6-yl]thio]-1-oxopropyl]-, 1,1-dimethylethyl ester
CAS No.:684288-61-7
Molecular Formula:C31H35FN4O6S
Molecular Weight:610.707
Hs Code.:

1-Piperazinecarboxylic acid,
4-[3-[[7-[(4-fluorophenyl)methyl]-7,8-dihydro-9-hydroxy-5-methoxy-8-oxo
-6H-pyrrolo[3,4-g]quinolin-6-yl]thio]-1-oxopropyl]-, 1,1-dimethylethyl
ester

Synonyms:

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Chemical Property of 1-Piperazinecarboxylic acid, 4-[3-[[7-[(4-fluorophenyl)methyl]-7,8-dihydro-9-hydroxy-5-methoxy-8-oxo -6H-pyrrolo[3,4-g]quinolin-6-yl]thio]-1-oxopropyl]-, 1,1-dimethylethyl ester

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Technology Process of 1-Piperazinecarboxylic acid, 4-[3-[[7-[(4-fluorophenyl)methyl]-7,8-dihydro-9-hydroxy-5-methoxy-8-oxo -6H-pyrrolo[3,4-g]quinolin-6-yl]thio]-1-oxopropyl]-, 1,1-dimethylethyl ester

There total 6 articles about 1-Piperazinecarboxylic acid, 4-[3-[[7-[(4-fluorophenyl)methyl]-7,8-dihydro-9-hydroxy-5-methoxy-8-oxo -6H-pyrrolo[3,4-g]quinolin-6-yl]thio]-1-oxopropyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 684284-49-9
3-[7-(4-fluoro-benzyl)-9-hydroxy-5-methoxy-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-6-ylsulfanyl]-propionic acid

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 684288-61-7
4-{3-[7-(4-fluoro-benzyl)-9-hydroxy-5-methoxy-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-6-ylsulfanyl]-propionyl}-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With TEA; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1016/j.bmcl.2006.05.008

Reference yield:

: 684284-29-5
7-(4-fluoro-benzyl)-5,9-dihydroxy-pyrrolo[3,4-g]quinoline-6,8-dione

: 684288-61-7
4-{3-[7-(4-fluoro-benzyl)-9-hydroxy-5-methoxy-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-6-ylsulfanyl]-propionyl}-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole / dimethylformamide / 36 h

2: K₂CO₃ / acetonitrile / 5 h / 40 °C

3: NaBH₄ / methanol; CH₂Cl₂ / 5 h

4: TFA / CH₂Cl₂ / 5 h / 20 °C

5: LiOH / tetrahydrofuran; methanol; H₂O / 1 h

6: EDC; TEA / CH₂Cl₂ / 15 h / 20 °C

With 1H-imidazole; lithium hydroxide; sodium tetrahydroborate; TEA; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2006.05.008

Reference yield:

: 684284-48-8
3-[7-(4-fluoro-benzyl)-9-hydroxy-5-methoxy-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-6-ylsulfanyl]-propionic acid methyl ester

: 684288-61-7
4-{3-[7-(4-fluoro-benzyl)-9-hydroxy-5-methoxy-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-6-ylsulfanyl]-propionyl}-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: LiOH / tetrahydrofuran; methanol; H₂O / 1 h

2: EDC; TEA / CH₂Cl₂ / 15 h / 20 °C

With lithium hydroxide; TEA; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2006.05.008