Cyclohexanecarboxylic acid, 2-oxo-1-[(2E)-3-phenyl-2-propenyl]-, ethyl ester, (1S)-

Base Information

• Chemical Name: Cyclohexanecarboxylic acid, 2-oxo-1-[(2E)-3-phenyl-2-propenyl]-, ethyl ester, (1S)-
• CAS No.: 685139-80-4
• Molecular Formula: C18H22O3
• Molecular Weight: 286.371
• Mol file: 685139-80-4.mol

Synonyms:

Chemical Property of Cyclohexanecarboxylic acid, 2-oxo-1-[(2E)-3-phenyl-2-propenyl]-, ethyl ester, (1S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanecarboxylic acid, 2-oxo-1-[(2E)-3-phenyl-2-propenyl]-, ethyl ester, (1S)-

There total 5 articles about Cyclohexanecarboxylic acid, 2-oxo-1-[(2E)-3-phenyl-2-propenyl]-, ethyl ester, (1S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cinnamyl acetate (21040-45-9) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl (1S)-2-oxo-1-[(2E)-3-phenylprop-2-en-1-yl]cyclohexanecarboxylate (685139-80-4) + ethyl (1R)-2-oxo-1-[(2E)-3-phenylprop-2-en-1-yl]cyclohexanecarboxylate

Guidance literature:

With N,O-bis-(trimethylsilyl)-acetamide; P-chirogenic diaminophosphine oxide; zinc diacetate; bis(η3-allyl-μ-chloropalladium(II)); In toluene; at 20 ℃; for 16h; Title compound not separated from byproducts;

DOI:10.1021/ja031792a

Reference yield:

Cinnamyl acetate (21040-45-9) + ethyl 2-(trimethylsilyloxy)cyclohex-1-enecarboxylate (74063-89-1) → ethyl (1S)-2-oxo-1-[(2E)-3-phenylprop-2-en-1-yl]cyclohexanecarboxylate (685139-80-4) + ethyl (1R)-2-oxo-1-[(2E)-3-phenylprop-2-en-1-yl]cyclohexanecarboxylate

Guidance literature:

With N,O-bis-(trimethylsilyl)-acetamide; bis(η3-allyl-μ-chloropalladium(II)); (S,R_P)-phenyl-P-chirogenic diaminophosphine oxide; zinc diacetate; In toluene; at 20 ℃; for 16h; Title compound not separated from byproducts;

DOI:10.1021/jo050800y

Reference yield:

Cinnamyl acetate (21040-45-9) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl (1S)-2-oxo-1-[(2E)-3-phenylprop-2-en-1-yl]cyclohexanecarboxylate (685139-80-4)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); 5,10,15,20-tetrakis(4-{(2R,5S)-3-phenyl-1,3-diaza-2-phosphabicyclo[3.3.0]octyloxy}phenyl)porphin; zinc diacetate; N,N-bis(trimethylsilyl)acetamide; In toluene; for 48h;

DOI:10.1134/S107042801508028X

upstream raw materials:

Cinnamyl acetate

ethyl 2-oxocyclohexane carboxylate

ethyl 2-(trimethylsilyloxy)cyclohex-1-enecarboxylate

cinnamyl acetate

Downstream raw materials:

[(R)-6-((E)-3-Phenyl-allyl)-1,4-dioxa-spiro[4.5]dec-6-yl]-methanol