1H-Indole-1-carboxylic acid, 2-[1,2,3,4-tetrahydro-4-oxo-1-[(phenylmethoxy)carbonyl]-5-[tris(1-methyl ethyl)silyl]-2-pyridinyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1H-Indole-1-carboxylic acid, 2-[1,2,3,4-tetrahydro-4-oxo-1-[(phenylmethoxy)carbonyl]-5-[tris(1-methyl ethyl)silyl]-2-pyridinyl]-, 1,1-dimethylethyl ester
CAS No.:685568-28-9
Molecular Formula:C35H46N2O5Si
Molecular Weight:602.846
Hs Code.:

1H-Indole-1-carboxylic acid,
2-[1,2,3,4-tetrahydro-4-oxo-1-[(phenylmethoxy)carbonyl]-5-[tris(1-methyl
ethyl)silyl]-2-pyridinyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of 1H-Indole-1-carboxylic acid, 2-[1,2,3,4-tetrahydro-4-oxo-1-[(phenylmethoxy)carbonyl]-5-[tris(1-methyl ethyl)silyl]-2-pyridinyl]-, 1,1-dimethylethyl ester

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MSDS Files:: SDS file from LookChem

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Technology Process of 1H-Indole-1-carboxylic acid, 2-[1,2,3,4-tetrahydro-4-oxo-1-[(phenylmethoxy)carbonyl]-5-[tris(1-methyl ethyl)silyl]-2-pyridinyl]-, 1,1-dimethylethyl ester

There total 3 articles about 1H-Indole-1-carboxylic acid, 2-[1,2,3,4-tetrahydro-4-oxo-1-[(phenylmethoxy)carbonyl]-5-[tris(1-methyl ethyl)silyl]-2-pyridinyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 99275-46-4
2-iodoindole-1-carboxylic acid tert-butyl ester

: 1-benzyloxycarbonyl-4-methoxy-3-triisopropylsilanyl-pyridinium; chloride

: 685568-28-9
1-[(benzyloxy)carbonyl]-2-[(1-tert-butoxycarbonyl)-2-indolyl]-5-(triisopropylsilyl)-2,3-dihydro-4-pyridone

Guidance literature:: 2-iodoindole-1-carboxylic acid tert-butyl ester; With methylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 1h;

1-benzyloxycarbonyl-4-methoxy-3-triisopropylsilanyl-pyridinium; chloride; In tetrahydrofuran; toluene; at -40 ℃; for 2h;
DOI:10.1021/jo049943v

Reference yield:

: 126378-42-5
4-methoxy-3-(trisopropylsilyl)pyridine

: 685568-28-9
1-[(benzyloxy)carbonyl]-2-[(1-tert-butoxycarbonyl)-2-indolyl]-5-(triisopropylsilyl)-2,3-dihydro-4-pyridone

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 0.67 h / -23 °C

2.1: MeMgBr / tetrahydrofuran / 1 h / 20 °C

2.2: 78 percent / toluene; tetrahydrofuran / 2 h / -40 °C

With methylmagnesium bromide; In tetrahydrofuran; toluene;
DOI:10.1021/jo049943v

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 685568-28-9
1-[(benzyloxy)carbonyl]-2-[(1-tert-butoxycarbonyl)-2-indolyl]-5-(triisopropylsilyl)-2,3-dihydro-4-pyridone

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 0.67 h / -23 °C

2.1: MeMgBr / tetrahydrofuran / 1 h / 20 °C

2.2: 78 percent / toluene; tetrahydrofuran / 2 h / -40 °C

With methylmagnesium bromide; In tetrahydrofuran; toluene;
DOI:10.1021/jo049943v