(2R)-2-amino-4-phosphonobutanoic acid

Base Information

Chemical Name:(2R)-2-amino-4-phosphonobutanoic acid
CAS No.:78739-01-2
Molecular Formula:C4H10NO5P
Molecular Weight:183.101
Hs Code.:
UNII:D27J5G57JL
Nikkaji Number:J264.953E
Wikidata:Q27076982
Pharos Ligand ID:Y2NLCHC2GUSC
ChEMBL ID:CHEMBL1319383
Mol file:78739-01-2.mol

Synonyms:D-AP4;78739-01-2;(2R)-2-amino-4-phosphonobutanoic acid;(R)-2-Amino-4-phosphonobutanoic acid;Butanoic acid, 2-amino-4-phosphono-, (2R)-;D27J5G57JL;D-2-amino-4-phosphonobutanoic acid;d(-)-2-amino-4-phosphonobutyric acid;2-Amino-4-phosphonobutyric acid, (R)-;d-(-)-2-amino-4-phosphonobutanoic acid;Butanoic acid, 2-amino-4-phosphono-, (R)-;D-2-Amino-4-phosphonobutyric acid;Tocris-0101;Tocris-0102;D-APB;Lopac-A-1910;D0G7TT;UNII-D27J5G57JL;GTPL1443;CHEMBL1319383;SCHEMBL12648443;BDBM82006;PDSP1_000361;PDSP2_000359;(R)-2-Amino-4-phosphonobutanoicacid;(r)-2-amino-4-phosphonobutyric acid;AKOS024456336;D-(-)-2-Amino-4-phosphonobutyric acid;NCGC00015041-01;NCGC00015041-02;NCGC00024466-01;NCGC00024467-01;HY-100781;CS-0020418;M01255;SR-01000597691;SR-01000597691-1;Q27076982

Suppliers and Price of (2R)-2-amino-4-phosphonobutanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
DLGAP4
100ul
$ 499.00

TRC
D(-)-2-Amino-4-phosphonobutanoicAcid(D-AP4)
2.5mg
$ 210.00

Tocris
D-AP4 ≥98%(HPLC)
50
$ 645.00

Tocris
D-AP4 ≥98%(HPLC)
10
$ 154.00

ApexBio Technology
D-AP4
10mg
$ 259.00

ApexBio Technology
D-AP4
50mg
$ 1095.00

American Custom Chemicals Corporation
D-AP4 95.00%
10MG
$ 750.70

Total 10 raw suppliers

Chemical Property of (2R)-2-amino-4-phosphonobutanoic acid

Chemical Property:

Appearance/Colour:white to off-white powder
Vapor Pressure:5.18E-11mmHg at 25°C
Melting Point:212-213 °C
Refractive Index:1.545
Boiling Point:491.7 °C at 760 mmHg
Flash Point:251.2 °C
PSA：130.66000
Density:1.628g/cm³
LogP:-0.33360
Storage Temp.:0-6°C
Solubility.:Aqueous Acid (Slightly), Water (Slightly)
XLogP3:-5.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:183.02965942
Heavy Atom Count:11
Complexity:187

Purity/Quality:

98%Min ^*data from raw suppliers

DLGAP4 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(CP(=O)(O)O)C(C(=O)O)N
Isomeric SMILES:C(CP(=O)(O)O)[C@H](C(=O)O)N
Uses D(-)-2-Amino-4-phosphonobutanoic acid (D-AP4) is an NMDA broad spectrum excitatory amino acid receptor antagonist.

Technology Process of (2R)-2-amino-4-phosphonobutanoic acid

There total 7 articles about (2R)-2-amino-4-phosphonobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 141894-89-5
2(R)-amino-4-(diethoxyphosphoryl)butanoic acid

: 78739-01-2
D-AP 4

Guidance literature:: With hydrogenchloride; for 7h; Heating;
DOI:10.1016/j.tet.2006.06.018

Reference yield:

: 86554-31-6
2-Amino-4-(dimethoxy-phosphoryl)-butyric acid methyl ester

: 6323-99-5,20263-07-4,23052-81-5,78739-01-2
2-Amino-4-phosphono-butyric acid

: 6323-99-5,20263-07-4,23052-81-5,78739-01-2
2-Amino-4-phosphono-butyric acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In water; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(01)91895-2

Reference yield:

: 86554-31-6
2-Amino-4-(dimethoxy-phosphoryl)-butyric acid methyl ester

: 6323-99-5,20263-07-4,23052-81-5,78739-01-2
2-Amino-4-phosphono-butyric acid

: 6323-99-5,20263-07-4,23052-81-5,78739-01-2
2-Amino-4-phosphono-butyric acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In water; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(01)91895-2