2-(6-Amino-2-chloropurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol

Base Information

Chemical Name:2-(6-Amino-2-chloropurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol
CAS No.:53458-23-4
Molecular Formula:C10H11Cl2N5O3
Molecular Weight:320.132
Hs Code.:
NSC Number:166152
DSSTox Substance ID:DTXSID90304529
Mol file:53458-23-4.mol

Synonyms:53458-23-4;NSC166152;DTXSID90304529;NSC-166152;2-Chloro-9-(5-chloro-5-deoxypentofuranosyl)-9H-purin-6-amine

Suppliers and Price of 2-(6-Amino-2-chloropurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2-(6-Amino-2-chloropurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol

Chemical Property:

Vapor Pressure:7.69E-14mmHg at 25°C
Boiling Point:570.2°Cat760mmHg
Flash Point:298.6°C
Density:2.14g/cm³
XLogP3:0.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:319.0238946
Heavy Atom Count:20
Complexity:368

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CCl)O)O)Cl)N

Technology Process of 2-(6-Amino-2-chloropurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol

There total 4 articles about 2-(6-Amino-2-chloropurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: C₁₀H₁₂ClN₅O₄

: 53458-23-4
(2R,3R,4S,5S)-2-(6-amino-2-chloro-9H-purin-9-yl)-5-(chloromethyl)tetrahydrofuran-3,4-diol

Guidance literature:: C₁₀H₁₂ClN₅O₄; With pyridine; thionyl chloride; In acetonitrile; at 0 - 20 ℃; for 19h;

With ammonium hydroxide; In methanol; water; at 20 ℃; for 0.5h;
DOI:10.1002/anie.201908681

Reference yield:

: C₁₄H₁₅Cl₂N₅O₅

: 53458-23-4
(2R,3R,4S,5S)-2-(6-amino-2-chloro-9H-purin-9-yl)-5-(chloromethyl)tetrahydrofuran-3,4-diol

Guidance literature:: With ammonia; In methanol; at 25 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c6cc09213f

Reference yield:

: 1839-18-5
2-chloroadenine

: 185453-73-0
1,2,3-tri-O-acetyl-5-deoxy-5-chloro-β-D-ribofuranose

: 53458-23-4
(2R,3R,4S,5S)-2-(6-amino-2-chloro-9H-purin-9-yl)-5-(chloromethyl)tetrahydrofuran-3,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate / acetonitrile / 4 h / 100 °C / Inert atmosphere

2: ammonia / methanol / 1 h / 25 °C / Inert atmosphere

With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; ammonia; In methanol; acetonitrile;
DOI:10.1039/c6cc09213f