5-((4-(2-(1H-Indol-1-yl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione

Base Information

Chemical Name:5-((4-(2-(1H-Indol-1-yl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
CAS No.:172647-53-9
Molecular Formula:C20H18N2O3S
Molecular Weight:366.441
Hs Code.:
DSSTox Substance ID:DTXSID50938182
Nikkaji Number:J955.129H
ChEMBL ID:CHEMBL418695

Synonyms:5-((4-(2-(1-indolyl)ethoxy)-phenyl)methyl)thiazolidine-2,4-dione;DRF 2189;DRF-2189

Suppliers and Price of 5-((4-(2-(1H-Indol-1-yl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-((4-(2-(1H-Indol-1-yl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione

Chemical Property:

Vapor Pressure:2.82E-15mmHg at 25°C
Boiling Point:619.5°Cat760mmHg
Flash Point:328.5°C
Density:1.34g/cm³
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:366.10381361
Heavy Atom Count:26
Complexity:521

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C=CN2CCOC3=CC=C(C=C3)CC4C(=O)NC(=O)S4

Technology Process of 5-((4-(2-(1H-Indol-1-yl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione

There total 7 articles about 5-((4-(2-(1H-Indol-1-yl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 5-[[4-[2-(1-indolyl)ethoxy]phenyl]methylene]thiazolidine-2,4-dione

: 172647-53-9
5-{4-[2-(1-indolyl)ethoxy]phenylmethyl}thiazolidine-2,4-dione

Guidance literature:: With hydrogen; palladium on activated charcoal; In 1,4-dioxane; under 3102.9 Torr;
DOI:10.1021/jm970444e

Reference yield: 82.0%

: C₂₀H₁₆N₂O₃S

: 172647-53-9
5-{4-[2-(1-indolyl)ethoxy]phenylmethyl}thiazolidine-2,4-dione

Guidance literature:: With sodium tetrahydroborate; cobalt dimethylglyoxime; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 35 - 40 ℃; for 24h;
DOI:10.1016/j.bmcl.2018.03.051

Reference yield:

: 120-72-9
indole

: 172647-53-9
5-{4-[2-(1-indolyl)ethoxy]phenylmethyl}thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodamide / 1.) DMSO, 25 deg C, 2.) DMSO

2: 78 percent / benzoic acid, piperidine / toluene / 1 h / Heating

3: 92 percent / H₂ / 10percent Pd/C / dioxane / 3102.9 Torr

With piperidine; hydrogen; sodium amide; benzoic acid; palladium on activated charcoal; In 1,4-dioxane; toluene;
DOI:10.1021/jm970444e