3,6,9,12-Tetraoxatetradecane-1,14-diamine

Base Information

• Chemical Name: 3,6,9,12-Tetraoxatetradecane-1,14-diamine
• CAS No.: 68960-97-4
• Molecular Formula: C10H24N2O4
• Molecular Weight: 236.312
• Hs Code.: 2942000090
• European Community (EC) Number: 811-125-2
• DSSTox Substance ID: DTXSID30436676
• Nikkaji Number: J1.160.176F
• Mol file: 68960-97-4.mol

Synonyms:68960-97-4;3,6,9,12-Tetraoxatetradecane-1,14-diamine;Amino-PEG4-Amine;1,14-diamino-3,6,9,12-tetraoxatetradecane;Amino-PEG4-C2-amine;H2N-PEG4-CH2CH2NH2;2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanamine;MFCD01365938;MFCD00132004;NH2-PEG4-NH2;SCHEMBL203118;LCZC1169;DTXSID30436676;IFZOPNLVYZYSMQ-UHFFFAOYSA-N;EX-A3868;AKOS024255744;BP-21684;HY-22335;SY056421;Triethylene Glycol Bis(2-aminoethyl) Ether;CS-0040777;T3198;EN300-370577;A866943

Chemical Property of 3,6,9,12-Tetraoxatetradecane-1,14-diamine

Chemical Property:

• Refractive Index: 1.4650 to 1.4690
• Boiling Point: 139°C/0.2mmHg(lit.)
• PKA: 9.04±0.10(Predicted)
• PSA: 88.96000
• Density: 1.043±0.06 g/cm3(Predicted)
• LogP: 0.37080
• Storage Temp.: -20°C
• Solubility.: Soluble in Water, DMSO, DCM, DMF
• XLogP3: -2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 13
• Exact Mass: 236.17360725
• Heavy Atom Count: 16
• Complexity: 113

Purity/Quality:

97% ^*data from raw suppliers

3,6,9,12-Tetraoxatetradecane-1,14-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COCCOCCOCCOCCN)N
• Description: Amino-PEG4-Amine is a very useful crosslinker containing two amino groups. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
• Uses: Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization

Technology Process of 3,6,9,12-Tetraoxatetradecane-1,14-diamine

There total 5 articles about 3,6,9,12-Tetraoxatetradecane-1,14-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,2'-(3,6,9,12-tetraoxatetradecane-1,14-diyl)bis(isoindoline-1,3-dione) (70110-27-9) → 1,14-diamino-3,6,9,12-tetraoxatetradecane (68960-97-4,892154-56-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 8h; Reflux;

DOI:10.1039/c2jm32726k

Reference yield: 84.0%

pentaethylene glycol dimesylate (109789-39-1) → 1,14-diamino-3,6,9,12-tetraoxatetradecane (68960-97-4,892154-56-2)

Guidance literature:

With ammonium hydroxide; tetrabutylammomium bromide; In dichloromethane; at 45 ℃; for 12h;

Reference yield: 80.0%

1,14-diazido-3,6,9,12-tetraoxatetradecane (182760-73-2,82055-94-5) → 1,14-diamino-3,6,9,12-tetraoxatetradecane (68960-97-4,892154-56-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 0 - 5 ℃; under 25858.1 Torr;

DOI:10.1021/acs.inorgchem.5b00748

upstream raw materials:

2,2'-(3,6,9,12-tetraoxatetradecane-1,14-diyl)bis(isoindoline-1,3-dione)

1,14-dichloro-3,6,9,12-tetraoxatetradecane

Pentaethylene glycol

pentaethylene glycol dimesylate