Chemical Property of 3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone
Chemical Property:
- Melting Point:117-118 °C
- PKA:11.65±0.60(Predicted)
- PSA：45.75000
- Density:1.10±0.1 g/cm3(Predicted)
- LogP:2.48410
- Storage Temp.:Refrigerator
- Solubility.:Chloroform (Slightly), Methanol (Slightly)
- Purity/Quality:
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97% *data from raw suppliers
AureusimineB *data from reagent suppliers
Safty Information:
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Useful:
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Description
Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears to be initiated by a conserved nonribosomal peptide synthetase that creates a dipeptide (phenylalanine-valine) aldehyde, which then undergoes cyclization and oxidation. Aureusimine B inhibits calpain in a casein hydrolysis assay (IC50 = 1.3 μM), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression.
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Uses
Aureusimine B is a novel small molecule isolated from S. aureus as one of a pair of related metabolites controversially identified as virulence factors in the pathology of Golden Staph. Aureusimine B
has also been reported as an inhibitor of the protease, calpain. Aureusimine B (phevalin) is a small molecular weight monoketopiperazine formed non-ribosomally by the fusion of phenylalanine and valine. Aureusimine B was isolated from S. aureus in 2010 as one of a pair of related metabolites, controversially identified as virulence factors in the pathology of Golden Staph. Aureusimine B is also an inhibitor of the protease, calpain.
