Pyrrolo[1,2-c]pyrimidine-2(1H)-carboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]imino]-4-formyl-3,5,6,7-tetrahydro-3-[9- [(4-methoxyphenyl)methoxy]nonyl]-, 1,1-dimethylethyl ester, (3R)-

Base Information

Chemical Name:Pyrrolo[1,2-c]pyrimidine-2(1H)-carboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]imino]-4-formyl-3,5,6,7-tetrahydro-3-[9- [(4-methoxyphenyl)methoxy]nonyl]-, 1,1-dimethylethyl ester, (3R)-
CAS No.:691006-78-7
Molecular Formula:C35H53N3O7
Molecular Weight:627.822
Hs Code.:

Pyrrolo[1,2-c]pyrimidine-2(1H)-carboxylic acid,
1-[[(1,1-dimethylethoxy)carbonyl]imino]-4-formyl-3,5,6,7-tetrahydro-3-[9-
[(4-methoxyphenyl)methoxy]nonyl]-, 1,1-dimethylethyl ester, (3R)-

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Chemical Property of Pyrrolo[1,2-c]pyrimidine-2(1H)-carboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]imino]-4-formyl-3,5,6,7-tetrahydro-3-[9- [(4-methoxyphenyl)methoxy]nonyl]-, 1,1-dimethylethyl ester, (3R)-

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Technology Process of Pyrrolo[1,2-c]pyrimidine-2(1H)-carboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]imino]-4-formyl-3,5,6,7-tetrahydro-3-[9- [(4-methoxyphenyl)methoxy]nonyl]-, 1,1-dimethylethyl ester, (3R)-

There total 12 articles about Pyrrolo[1,2-c]pyrimidine-2(1H)-carboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]imino]-4-formyl-3,5,6,7-tetrahydro-3-[9- [(4-methoxyphenyl)methoxy]nonyl]-, 1,1-dimethylethyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 691006-70-9
1-tert-butoxycarbonylimino-4-hydroxymethyl-3-[9-(4-methoxy-benzyloxy)-nonyl]-hexahydro-pyrrolo[1,2-c]pyrimidine-2-carboxylic acid tert-butyl ester

: 691006-78-7
1-tert-butoxycarbonylimino-4-formyl-3-[9-(4-methoxy-benzyloxy)-nonyl]-3,5,6,7-tetrahydro-pyrrolo[1,2-c]pyrimidine-2-carboxylic acid tert-butyl ester

Guidance literature:: With 4 A molecular sieve; 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate; In dichloromethane;
DOI:10.1002/anie.200353200

Reference yield: 11.0%

: 691006-70-9
1-tert-butoxycarbonylimino-4-hydroxymethyl-3-[9-(4-methoxy-benzyloxy)-nonyl]-hexahydro-pyrrolo[1,2-c]pyrimidine-2-carboxylic acid tert-butyl ester

: 691006-78-7
1-tert-butoxycarbonylimino-4-formyl-3-[9-(4-methoxy-benzyloxy)-nonyl]-3,5,6,7-tetrahydro-pyrrolo[1,2-c]pyrimidine-2-carboxylic acid tert-butyl ester

: 1-tert-butoxycarbonylimino-4-formyl-4-hydroxy-3-[9-(4-methoxy-benzyloxy)-nonyl]-hexahydro-pyrrolo[1,2-c]pyrimidine-2-carboxylic acid tert-butyl ester

Guidance literature:: With dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In toluene;
DOI:10.1002/anie.200353200

Reference yield:

: 691006-73-2
(2S,3S,3aR,4S)-3-Hydroxymethyl-2-[9-(4-methoxy-benzyloxy)-nonyl]-hexahydro-pyrrolo[1,2-b]isoxazol-4-ol

: 691006-78-7
1-tert-butoxycarbonylimino-4-formyl-3-[9-(4-methoxy-benzyloxy)-nonyl]-3,5,6,7-tetrahydro-pyrrolo[1,2-c]pyrimidine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 81 percent / pyridine / 19 h / 20 °C

2: 58 percent / DMAP; pyridine / 20 h / 20 °C

3: 94 percent / n-Bu₃SnH; AIBN / toluene / 0.5 h / 110 °C

4: H₂ / Pd(OH)2/C / ethanol / 3 h / 20 °C

5: 830 mg / HgCl₂; Et₃N / dimethylformamide / 0.5 h / 20 °C

6: 100 percent / DEAD; PPh₃ / toluene / 0.5 h / 20 °C

7: 580 mg / TBAF / tetrahydrofuran / 2 h / 20 °C

8: 47 percent / tetra-n-propylammonium perruthenate; NMO; 4 Angstroem molecular sieves / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; dmap; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; tri-n-butyl-tin hydride; triethylamine; triphenylphosphine; mercury dichloride; diethylazodicarboxylate; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 6: Mitsunobu reaction;
DOI:10.1002/chem.200500852