3-Phenyl-1H-indole-2-carbaldehyde

Base Information

• Chemical Name: 3-Phenyl-1H-indole-2-carbaldehyde
• CAS No.: 6915-66-8
• Molecular Formula: C15H11NO
• Molecular Weight: 221.258
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID80489899
• Nikkaji Number: J1.412.142K
• Wikidata: Q82333431
• Mol file: 6915-66-8.mol

Synonyms:3-Phenyl-1H-indole-2-carbaldehyde;6915-66-8;SCHEMBL5419384;DTXSID80489899;RQDBFQTUGJUCNJ-UHFFFAOYSA-N;AKOS022688638;CS-0454961;A937098

Chemical Property of 3-Phenyl-1H-indole-2-carbaldehyde

Chemical Property:

• PSA: 32.86000
• LogP: 3.64740
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 221.084063974
• Heavy Atom Count: 17
• Complexity: 272

Purity/Quality:

95% ^*data from raw suppliers

3-Phenyl-1H-indole-2-carbaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(NC3=CC=CC=C32)C=O

Technology Process of 3-Phenyl-1H-indole-2-carbaldehyde

There total 10 articles about 3-Phenyl-1H-indole-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-(2-(1-hydroxy-1-phenylprop-2-ynyl)phenyl)acetamide (1448531-98-3) → 3-phenyl-1H-indole-2-carbaldehyde (6915-66-8)

Guidance literature:

With N-iodo-succinimide; In water; acetone; for 24h; Reflux;

DOI:10.1016/j.tet.2013.06.032

Reference yield: 53.0%

3-phenyl-1H-indole (1504-16-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-phenyl-1H-indole-2-carbaldehyde (6915-66-8) + 3-phenylindole-1-carboxaldehyde (83824-09-3)

Guidance literature:

With trichlorophosphate; at 120 - 140 ℃; for 1h;

DOI:10.1002/jhet.5570370543

Reference yield: 11.0%

2-methyl-3-phenyl-1H-indole (4757-69-1) → 3-phenyl-1H-indole-2-carbaldehyde (6915-66-8) + 3-phenyl-1H-indole-2-carboxylic acid (6915-67-9) + 5,6,11b,12-tetrahydro-11b,13-diphenyl-pyrido[1,2-a:5,4-b']diindole-6-one

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; at 130 ℃; for 5h;

DOI:10.1002/jhet.5570370543

upstream raw materials:

3-phenyl-1H-indole

N,N-dimethyl-formamide

(3-phenylindol-2-yl)methanol

2-methyl-3-phenyl-1H-indole

Downstream raw materials:

2,2-dimethyl-5-(3'-phenylindol-2'-ylmethylene)-1,3-dioxan-4,6-dione

3-phenyl-1-tosyl-1H-indole-2-carbaldehyde