Octahydro-2-methyl-2H-quinolizine

Base Information

• Chemical Name: Octahydro-2-methyl-2H-quinolizine
• CAS No.: 4939-37-1
• Molecular Formula: C10H19N
• Molecular Weight: 0
• Mol file: 4939-37-1.mol

Synonyms:2-Methyl-chinolizidin-'A'-racemat;2-Methyl-octahydro-quinolizine;2-Methyl-chinolizidin-'B'-racemat;

Chemical Property of Octahydro-2-methyl-2H-quinolizine

Chemical Property:

• PSA: 3.24000
• LogP: 2.20870

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Octahydro-2-methyl-2H-quinolizine

There total 17 articles about Octahydro-2-methyl-2H-quinolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-hexahydro-quinolizin-1-one (99188-84-8) → (+/-)-2c-methyl-(9ar)-octahydro-quinolizin (4939-37-1,5581-90-8,5591-02-6)

Guidance literature:

With hydrazine hydrate; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; at 230 ℃; Erhitzen des Reaktionsgemisches mit Kaliumhydroxid auf 220grad;

DOI:10.1021/ja01595a054 DOI:10.1039/jr9370001518

Reference yield:

2-methyl-octahydro-quinolizin-2-ol (31101-16-3) → 2-methylquinolizidine (4939-37-1,5581-90-8,5591-02-6) + (+/-)-2c-methyl-(9ar)-octahydro-quinolizin (4939-37-1,5581-90-8,5591-02-6)

Guidance literature:

With phosphoric acid; phosphorus pentoxide; at 150 ℃; Hydrieren des Reaktionsprodukts an Raney-Nickel in Aethanol;

DOI:10.1021/ja01595a054

Reference yield:

2-methyl-octahydro-quinolizin-2-ol (31101-16-3) → 2-methylquinolizidine (4939-37-1,5581-90-8,5591-02-6) + (+/-)-2c-methyl-(9ar)-octahydro-quinolizin (4939-37-1,5581-90-8,5591-02-6)

Guidance literature:

With phosphoric acid; phosphorus pentoxide; at 150 ℃; Hydrieren des Reaktionsprodukts an Raney-Nickel in Aethanol;

DOI:10.1021/ja01595a054

upstream raw materials:

eq-quinolizidin-2-ylmethanol

2-methyl-octahydro-quinolizin-2-ol

2-methylquinolizinium bromide

hex-5-enenitrile

Refernces

• 1、 Molander, Gary A.,Pack, Shawn K.. "Determining the Scope of the Organolanthanide-Catalyzed, Sequential Intramolecular Amination/Cyclization Reaction: Formation of Substituted Quinolizidines, Indolizidines, and Pyrrolizidines". . p. 9214 - 9220. Retrieved 2007/10/03.