4-[2-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINOL

Base Information

• Chemical Name: 4-[2-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINOL
• CAS No.: 69908-12-9
• Molecular Formula: C12H14F3NO
• Molecular Weight: 245.244
• Mol file: 69908-12-9.mol

Synonyms:4-[2-(Trifluoromethyl)phenyl]-4-piperidinol HCl;4-[2-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINOL;

Chemical Property of 4-[2-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINOL

Chemical Property:

• PSA: 32.26000
• LogP: 2.60520

Purity/Quality:

95%-98% ^*data from raw suppliers

4-[2-(Trifluoromethyl)phenyl]-4-piperidinolhydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[2-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINOL

There total 3 articles about 4-[2-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ 4-(2-(trifluoromethyl)phenyl)piperidin-4-ol (69908-12-9)

Guidance literature:

Reference yield:

1-benzyl-4-hydroxy-4-(2-tri-fluoromethylphenyl)piperidine (208989-32-6) → 4-(2-(trifluoromethyl)phenyl)piperidin-4-ol (69908-12-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 35 ℃; under 760.051 Torr;

Reference yield:

tert-butyl 4-hydroxy-4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxylate (871112-34-4) → 4-(2-(trifluoromethyl)phenyl)piperidin-4-ol (69908-12-9)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃;

upstream raw materials:

1-benzyl-4-hydroxy-4-(2-tri-fluoromethylphenyl)piperidine

tert-butyl 4-hydroxy-4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxylate

Downstream raw materials:

tert-butyl 4-hydroxy-4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxylate

Refernces

• 1、 -. "3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS". Page/Page column 31. . Retrieved 2008/06/13.
• 2、 -. "INDOLE DERIVATIVE AND USE FOR TREATMENT OF CANCER". Page/Page column 254. . Retrieved 2010/02/15.