2-(4-FLUOROPHENYL)-1H-INDOLE-3-CARBOXAL&

Base Information

• Chemical Name: 2-(4-FLUOROPHENYL)-1H-INDOLE-3-CARBOXAL&
• CAS No.: 70093-12-8
• Molecular Formula: C15H10FNO
• Molecular Weight: 239.249
• Hs Code.: 2933990090
• Mol file: 70093-12-8.mol

Synonyms:2-(4-Fluorophenyl)-1H-indole-3-carboxaldehyde;2-(4-fluoro-phenyl)-indole-3-carbaldehyde;1H-INDOLE-3-CARBOXALDEHYDE,2-(4-FLUOROPHENYL);2-(4-fluorophenyl)-indole-3-carboxaldehyde;

Chemical Property of 2-(4-FLUOROPHENYL)-1H-INDOLE-3-CARBOXAL&

Chemical Property:

• Vapor Pressure: 1.32E-08mmHg at 25°C
• Melting Point: 254-259oC (dec.)(lit.)
• Boiling Point: 459oC at 760 mmHg
• Flash Point: 231.4oC
• PSA: 32.86000
• Density: 1.307g/cm3
• LogP: 3.78650
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Fluorophenyl)-1H-indole-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-FLUOROPHENYL)-1H-INDOLE-3-CARBOXAL&

There total 4 articles about 2-(4-FLUOROPHENYL)-1H-INDOLE-3-CARBOXAL& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(4-fluorophenyl)indole (782-17-2) → 2-(p-fluorophenyl)-1H-indole-3-carboxaldehyde (70093-12-8)

Guidance literature:

2-(4-fluorophenyl)indole; With N,N-dimethyl-formamide; trichlorophosphate; at 10 - 50 ℃;

With sodium hydrogencarbonate; In water; at 60 ℃; for 0.25h;

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → 2-(p-fluorophenyl)-1H-indole-3-carboxaldehyde (70093-12-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; ethanol

2: polyphosphoric acid

3: trichlorophosphate

With trichlorophosphate; In ethanol; acetic acid; 3: |Vilsmeier-Haack Formylation;

DOI:10.1007/s00044-011-9861-4

Reference yield:

1-(1-(4-fluorophenyl)ethylidene)-2-phenylhydrazine (1994-40-7) → 2-(p-fluorophenyl)-1H-indole-3-carboxaldehyde (70093-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric acid

2: trichlorophosphate

With trichlorophosphate; 2: |Vilsmeier-Haack Formylation;

DOI:10.1007/s00044-011-9861-4

upstream raw materials:

2-(4-fluorophenyl)indole

1-(4-fluorophenyl)ethanone

1-(1-(4-fluorophenyl)ethylidene)-2-phenylhydrazine

Downstream raw materials:

5-<2-(4-fluorophenyl)-1H-indol-3-ylmethylene>-2,4,6(1H,3H,5H)-pyrimidinetrione

dihydro-5-<2-(4-fluorophenyl)-1H-indol-3-ylmethylene>-2-thioxo-4,6(1H,5H)-pyrimidinedione

C₁₆H₁₃FN₄S

butyl-[2-(4-fluoro-phenyl)-indol-3-ylmethylene]-amine