poly(2'-methylthioadenylic acid)

Base Information

• Chemical Name: poly(2'-methylthioadenylic acid)
• CAS No.: 70804-88-5
• Molecular Formula: C₁₁H₁₆N₅O₇PS
• Molecular Weight: 393.317
• Mol file: 70804-88-5.mol

Synonyms:Poly(2-methylthioadenylicacid)

Chemical Property of poly(2'-methylthioadenylic acid)

Chemical Property:

• PSA: 221.18000
• LogP: -0.55990

Purity/Quality:

97% ^*data from raw suppliers

Poly(2'-methylthioadenylicacid) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of poly(2'-methylthioadenylic acid)

There total 8 articles about poly(2'-methylthioadenylic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(methylthio)adenosine (4105-39-9) → 2-methylthioadenosine 5'-monophosphate (22140-20-1,70804-88-5)

Guidance literature:

With trichlorophosphate; In various solvent(s); at 5 ℃; for 18h;

Reference yield:

Phosphoric acid (3aR,4R,6R,6aR)-6-(6-amino-2-methylsulfanyl-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester di-tert-butyl ester (436847-42-6) → 2-methylthioadenosine 5'-monophosphate (22140-20-1,70804-88-5)

Guidance literature:

With DOWEX 50WX₈-200; In methanol; water; at 80 ℃; for 1h;

DOI:10.1021/jm010538v

Reference yield:

((3aR,4R,6R,6aR)-6-(6-amino-2-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol (24639-06-3) → 2-methylthioadenosine 5'-monophosphate (22140-20-1,70804-88-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 65 percent / dimethylformamide / 1.5 h / 90 °C

2: tetrazole / tetrahydrofuran / 20 °C

3: m-CPBA / tetrahydrofuran; CH₂Cl₂ / -78 - 20 °C

4: 3 mg / DOWEX 50Wx₈-200 / H₂O; methanol / 1 h / 80 °C

With 1H-tetrazole; DOWEX 50WX₈-200; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm010538v

upstream raw materials:

2-(methylthio)adenosine

Phosphoric acid (3aR,4R,6R,6aR)-6-(6-amino-2-methylsulfanyl-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester di-tert-butyl ester

((3aR,4R,6R,6aR)-6-(6-amino-2-chloro-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

(2R,3R,4S,5R)-2-(6-amino-2-methylsulfanyl-9H-purin-9-yl)tetrahydrofuran-3,4-(O-isopropylidene)