SH-6

Base Information

• Chemical Name: SH-6
• CAS No.: 701976-55-8
• Molecular Formula: C28H57O9P
• Molecular Weight: 568.72
• Mol file: 701976-55-8.mol

Synonyms:

Chemical Property of SH-6

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

SH-6 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of SH-6

There total 7 articles about SH-6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Phosphoric acid benzyl ester (R)-2-methoxy-3-octadecyloxy-propyl ester (1R,2R,3S,4R)-2,3,4-tris-benzyloxy-cyclohexyl ester → phosphoric acid 2-methoxy-3-octadecyloxy-propyl ester 2,3,4-trihydroxy-cyclohexyl ester (701976-55-8)

Guidance literature:

With hydrogen; 20percent Pd(OH)2/C; In tert-butyl alcohol; at 20 ℃; under 760.051 Torr;

DOI:10.1021/ja0285159

Reference yield:

1-O-octadecyl-2-O-methyl-sn-glycerol (83167-59-3) → phosphoric acid 2-methoxy-3-octadecyloxy-propyl ester 2,3,4-trihydroxy-cyclohexyl ester (701976-55-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / diisopropylammonium tetrazolide / CH₂Cl₂ / 1 h / 20 °C

2: 1H-tetrazole / CH₂Cl₂ / 20 °C

3: 149 mg / m-chloroperoxybenzoic acid / CH₂Cl₂ / 0 - 20 °C

4: 95 percent / H₂ / 20percent Pd(OH)2/C / 2-methyl-propan-2-ol / 20 °C / 760.05 Torr

With 1H-tetrazole; N,N-diisopropylamine tetrazolide; hydrogen; 3-chloro-benzenecarboperoxoic acid; 20percent Pd(OH)2/C; In dichloromethane; tert-butyl alcohol;

DOI:10.1021/ja0285159

Reference yield:

(1R,2R,3S,4S,5R)-3,4,5-Tris-benzyloxy-cyclohexane-1,2-diol (162792-20-3) → phosphoric acid 2-methoxy-3-octadecyloxy-propyl ester 2,3,4-trihydroxy-cyclohexyl ester (701976-55-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: Bu₂SnO / toluene / 2 h / Heating

1.2: 90 percent / CsF / dimethylformamide / 20 °C

2.1: 1H-tetrazole / CH₂Cl₂ / 20 °C

3.1: 149 mg / m-chloroperoxybenzoic acid / CH₂Cl₂ / 0 - 20 °C

4.1: 95 percent / H₂ / 20percent Pd(OH)2/C / 2-methyl-propan-2-ol / 20 °C / 760.05 Torr

With 1H-tetrazole; hydrogen; di(n-butyl)tin oxide; 3-chloro-benzenecarboperoxoic acid; 20percent Pd(OH)2/C; In dichloromethane; toluene; tert-butyl alcohol;

DOI:10.1021/ja0285159

upstream raw materials:

1-O-octadecyl-2-O-methyl-sn-glycerol

(1R,2R,3S,4S,5R)-3,4,5-Tris-benzyloxy-cyclohexane-1,2-diol

1D-4,5,6-tri-O-benzyl-2,3-dideoxy-myo-inositol

Diisopropyl-phosphoramidous acid benzyl ester (R)-2-methoxy-3-octadecyloxy-propyl ester

Refernces