1-(Thiophene-2-carbonyl)-pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:1-(Thiophene-2-carbonyl)-pyrrolidine-2-carboxylic acid
CAS No.:117918-58-8
Molecular Formula:C₁₀H₁₁NO₃S
Molecular Weight:225.268
Hs Code.:2934999090
DSSTox Substance ID:DTXSID30372388
ChEMBL ID:CHEMBL2132862
Mol file:117918-58-8.mol

Synonyms:117918-58-8;1-(Thiophene-2-carbonyl)-pyrrolidine-2-carboxylic acid;1-(thiophene-2-carbonyl)pyrrolidine-2-carboxylic acid;257946-35-3;1-(Thiophene-2-carbonyl)proline;1-(thiophen-2-ylcarbonyl)proline;BAS 01363726;SMR000062994;Maybridge1_007754;Oprea1_013471;Oprea1_660543;MLS000057953;(Thiophene-2-carbonyl)proline;SCHEMBL6290034;CHEMBL2132862;HMS563I10;DTXSID30372388;HMS2346J11;CCG-42571;MFCD00204055;STL182523;AKOS000121776;AKOS016165924;NCGC00041224-02;CS-0450431;EN300-00799;SR-01000601362-2;1-(thiophene-2-carbonyl)pyrrolidine-2-carboxylicacid;Z85891019;1-(THIOPHENE-2-CARBONYL)-PYRROLIDINE-2-CARBOXYLICACID;1-(thiophene-2-carbonyl)-pyrrolidine-2-carboxylic acid, AldrichCPR

Suppliers and Price of 1-(Thiophene-2-carbonyl)-pyrrolidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(Thiophen-2-ylcarbonyl)proline
100mg
$ 90.00

Matrix Scientific
1-(Thiophene-2-carbonyl)-pyrrolidine-2-carboxylic acid
1g
$ 378.00

Crysdot
1-(Thiophene-2-carbonyl)pyrrolidine-2-carboxylicacid 95+%
5g
$ 677.00

Atlantic Research Chemicals
1-(2-Thienylcarbonyl)proline 95%
1mg:
$ 42.41

American Custom Chemicals Corporation
1-(THIOPHENE-2-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID 95.00%
5G
$ 1210.63

American Custom Chemicals Corporation
1-(THIOPHENE-2-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID 95.00%
2.5G
$ 1011.60

American Custom Chemicals Corporation
1-(THIOPHENE-2-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID 95.00%
1G
$ 736.12

AK Scientific
1-(Thiophene-2-carbonyl)-pyrrolidine-2-carboxylicacid
1g
$ 560.00

Total 7 raw suppliers

Chemical Property of 1-(Thiophene-2-carbonyl)-pyrrolidine-2-carboxylic acid

Chemical Property:

Vapor Pressure:1.03E-08mmHg at 25°C
Boiling Point:445.3°Cat760mmHg
Flash Point:223.1°C
PSA：85.85000
Density:1.421g/cm³
LogP:1.37520
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:225.04596439
Heavy Atom Count:15
Complexity:282

Purity/Quality:

99%, ^*data from raw suppliers

1-(Thiophen-2-ylcarbonyl)proline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(N(C1)C(=O)C2=CC=CS2)C(=O)O

Technology Process of 1-(Thiophene-2-carbonyl)-pyrrolidine-2-carboxylic acid

There total 2 articles about 1-(Thiophene-2-carbonyl)-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5271-67-0
2-Thiophenecarbonyl chloride

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 117918-58-8
N-(2-Thenoyl)-L-proline

Guidance literature:: With sodium hydroxide; In acetone; at 0 ℃; for 1h;
DOI:10.1021/jm00122a028

Reference yield:

: 527-72-0
2-thiophenylcarboxylic acid

: 117918-58-8
N-(2-Thenoyl)-L-proline

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 2 h / Heating

2: 20percent aq. NaOH / acetone / 1 h / 0 °C

With sodium hydroxide; thionyl chloride; In acetone;
DOI:10.1021/jm00122a028