2-Cyclopentylpropanoic acid

Base Information

• Chemical Name: 2-Cyclopentylpropanoic acid
• CAS No.: 7028-22-0
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.198
• Hs Code.: 2916209090
• European Community (EC) Number: 857-969-5
• Mol file: 7028-22-0.mol

Synonyms:2-cyclopentylpropanoic acid;7028-22-0;2-cyclopentylpropanoicacid;SCHEMBL9307;MFCD08704263;AKOS011927346;AT29349;NS-01096;CS-0137663;EN300-100726;Z993955140

Chemical Property of 2-Cyclopentylpropanoic acid

Chemical Property:

• Melting Point: 238.5-241 °C
• Boiling Point: 119-119.5 °C(Press: 8 Torr)
• PKA: 4.84±0.10(Predicted)
• PSA: 37.30000
• Density: 1.0191 g/cm3(Temp: 0 °C)
• LogP: 1.89730
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 142.099379685
• Heavy Atom Count: 10
• Complexity: 125

Purity/Quality:

97% ^*data from raw suppliers

2-Cyclopentylpropanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1CCCC1)C(=O)O

Technology Process of 2-Cyclopentylpropanoic acid

There total 16 articles about 2-Cyclopentylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(2-oxo-cyclopentyl)-propionic acid (59591-06-9) → 2-cyclopentylpropanoic acid (7028-22-0)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In ethylene glycol; Heating; 1) 160-165 deg C 2) 4h, 195-200 deg C;

Reference yield:

2-(1-cyclopentenyl)-2-methylacetic acid (92000-97-0) → 2-cyclopentylpropanoic acid (7028-22-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 55 ℃; for 6h; under 2250.2 Torr;

Reference yield:

ethyl 2-cyclopentylpropanoate (36588-72-4) → 2-cyclopentylpropanoic acid (7028-22-0)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 70 ℃;

DOI:10.1021/jacs.0c07918

upstream raw materials:

cyclopentyl-methyl-malonic acid

diethyl 2-cyclopentyl-2-methylmalonate

2-cyclopentylpropanol

propionic acid