Cis-2-hydroxycyclopentanecarbonitrile

Base Information

Chemical Name:Cis-2-hydroxycyclopentanecarbonitrile
CAS No.:70367-34-9
Molecular Formula:C₆H₉NO
Molecular Weight:111.144
Hs Code.:
DSSTox Substance ID:DTXSID90466777
Nikkaji Number:J450.994C
Wikidata:Q82293405

Synonyms:Cis-2-hydroxycyclopentanecarbonitrile;70367-34-9;(1S,2S)-2-Hydroxycyclopentane-1-carbonitrile;196801-06-6;CTK2H4985;DTXSID90466777;cis-2-hydroxycyclo-pentanecarbonitrile

Suppliers and Price of Cis-2-hydroxycyclopentanecarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of Cis-2-hydroxycyclopentanecarbonitrile

Chemical Property:

Vapor Pressure:0.002mmHg at 25°C
PSA：44.02000
LogP:0.67098
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:111.068413911
Heavy Atom Count:8
Complexity:124

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(C(C1)O)C#N
Isomeric SMILES:C1C[C@H]([C@H](C1)O)C#N

Technology Process of Cis-2-hydroxycyclopentanecarbonitrile

There total 5 articles about Cis-2-hydroxycyclopentanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 285-67-6
Cyclopentene oxide

: 143-33-9,25596-52-5
sodium cyanide

: 57836-12-1,63578-08-5,68455-39-0,70367-34-9,133725-25-4
trans-2-Hydroxycyclopentanecarbonitrile

Guidance literature:: With hydrogenchloride; In water; at -10 ℃; for 168h;

Reference yield:

: 131750-48-6
(1S,2R)-2-Trimethylsilanyloxy-cyclopentanecarbonitrile

: 57836-12-1,63578-08-5,68455-39-0,70367-34-9,133725-25-4
trans-2-Hydroxycyclopentanecarbonitrile

Guidance literature:: With potassium fluoride; In methanol;
DOI:10.1021/ja005794w

Reference yield:

: 142-29-0
cyclopentene

: 57836-12-1,63578-08-5,68455-39-0,70367-34-9,133725-25-4
trans-2-Hydroxycyclopentanecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: [-OC(C₆H₅)2CH₂CH₂C(C₆H₅)2O-]Zr(O-tBu)2; Ph₃PO; bis(trimethylsilyl)peroxide / 1,2-dichloro-ethane / 5 h / 20 °C

2: KF / methanol

With potassium fluoride; [-OC(C₆H₅)2CH₂CH₂C(C₆H₅)2O-]Zr(O-tBu)2; bis-trimethylsilanyl peroxide; Triphenylphosphine oxide; In methanol; 1,2-dichloro-ethane;
DOI:10.1021/ja005794w