N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE

Base Information

• Chemical Name: N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE
• CAS No.: 70375-43-8
• Molecular Formula: C₁₅H₁₃N₃S
• Molecular Weight: 267.354
• Mol file: 70375-43-8.mol

Synonyms:AURORA KA-7903;

Chemical Property of N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE

Chemical Property:

• Vapor Pressure: 2.37E-06mmHg at 25°C
• Melting Point: 240.0-240.8oC(lit.)
• Boiling Point: 392oC at 760 mmHg
• Flash Point: 190.9oC
• PSA: 58.42000
• LogP: 4.08940
• Storage Temp.: Desiccate at +4°C
• Solubility.: DMSO: 40 mg/mL

Purity/Quality:

98%Min ^*data from raw suppliers

SCH 202676 hydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Description: SCH-202676 (70375-43-8) is a reversible inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs).1 IC50‘s = 0.1-1.7 μM for nine GPCRs.1 Modification of GPCRs is accomplished via sulfhydryl modification.2,3
• Uses: SCH-202676 hydrobromide is a modulator that inhibits binding to G protein-coupled receptors.

Technology Process of N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE

There total 2 articles about N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-3-[(phenyl)-(phenylimino)methyl]thiourea (70375-39-2) → (Z)-N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine (70375-43-8)

Guidance literature:

With iodine; In ethanol; dichloromethane;

Reference yield:

N-phenyl-benzimidoyl chloride (4903-36-0) → (Z)-N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine (70375-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O

2: I₂ / CH₂Cl₂; ethanol

With iodine; In ethanol; dichloromethane; water;

Reference yield:

(Z)-N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)methanamine (70375-43-8) → N',N'''-diphenyl-N,N''-(2,4-dimethyl-[1,2,4]thiadiazolidine-3,5-diylidene)-bis-benzamidine (70375-57-4)

Guidance literature:

at 180 ℃;

upstream raw materials:

1-methyl-3-[(phenyl)-(phenylimino)methyl]thiourea

N-phenyl-benzimidoyl chloride

Downstream raw materials:

N',N'''-diphenyl-N,N''-(2,4-dimethyl-[1,2,4]thiadiazolidine-3,5-diylidene)-bis-benzamidine

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