4-[4-(Dimethylamino)phenyl]-6-hydroxy-2-sulfanylpyrimidine-5-carbonitrile

Base Information

Chemical Name:4-[4-(Dimethylamino)phenyl]-6-hydroxy-2-sulfanylpyrimidine-5-carbonitrile
CAS No.:70638-55-0
Molecular Formula:C13H12N4OS
Molecular Weight:272.33
Hs Code.:
DSSTox Substance ID:DTXSID80966175

Synonyms:5185-15-9;4-[4-(dimethylamino)phenyl]-6-hydroxy-2-sulfanylpyrimidine-5-carbonitrile;ChemDiv3_007114;Oprea1_219896;TQR960;DTXSID80966175;HMS1493D08;STL266808;AKOS000270092;AKOS001735979;IDI1_025024;SR-01000528990;SR-01000528990-1;BRD-K70159463-001-01-2;4-(4-(dimethylamino)phenyl)-2-mercapto-6-oxo-1,6-dihydropyrimidine-5-carbonitrile;4-[4-(Dimethylamino)phenyl]-6-oxo-2-sulfanyl-1,6-dihydro-5-pyrimidinecarbonitrile;4-[4-(Dimethylamino)phenyl]-6-oxo-2-sulfanyl-1,6-dihydro-5-pyrimidinecarbonitrile #;4-[4-(dimethylamino)phenyl]-6-oxo-2-sulfanyl-1,6-dihydropyrimidine-5-carbonitrile;Pyrimidine-5-carbonitrile, 3,4-dihydro-6-(dimethylaminophenyl)-2-mercapto-4-oxo-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[4-(Dimethylamino)phenyl]-6-hydroxy-2-sulfanylpyrimidine-5-carbonitrile

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:272.07318219
Heavy Atom Count:19
Complexity:480

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)C#N

Technology Process of 4-[4-(Dimethylamino)phenyl]-6-hydroxy-2-sulfanylpyrimidine-5-carbonitrile

There total 3 articles about 4-[4-(Dimethylamino)phenyl]-6-hydroxy-2-sulfanylpyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 17356-08-0
thiourea

: 105-56-6
ethyl 2-cyanoacetate

: 100-10-7
4-dimethylamino-benzaldehyde

: 70638-55-0
6-(4-(dimethylamino)phenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

Guidance literature:: With potassium carbonate; In ethanol; Reflux;
DOI:10.2174/1570180817999201022193325

Reference yield:

: 17356-08-0
thiourea

: 105-56-6
ethyl 2-cyanoacetate

: 100-10-7
4-dimethylamino-benzaldehyde

: 70638-55-0
C₁₃H₁₂N₄OS

Guidance literature:: thiourea; ethyl 2-cyanoacetate; 4-dimethylamino-benzaldehyde; With potassium carbonate; In ethanol; for 12h; Reflux;

With acetic acid; In ethanol;
DOI:10.1016/j.ejmech.2011.02.052