L-Tyrosine, 2-methyl-

Base Information

• Chemical Name: L-Tyrosine, 2-methyl-
• CAS No.: 70680-92-1
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• DSSTox Substance ID: DTXSID90358663
• Nikkaji Number: J303.821A
• Mol file: 70680-92-1.mol

Synonyms:70680-92-1;L-Tyrosine, 2-methyl-;2-METHYL-L-TYROSINE;0-methyl-tyrosine;(o-methyltyrosine);SCHEMBL38096;(2S)-2-amino-3-(4-hydroxy-2-methylphenyl)propanoic acid;DTXSID90358663;AXEOMQHKTSGLGS-VIFPVBQESA-N;AKOS006285120;AT32991;(S)-2-Amino-3-(4-hydroxy-2-methylphenyl)propanoic acid;(S)-2-Amino-3-(4-hydroxy-2-methylphenyl)propanoicacid

Chemical Property of L-Tyrosine, 2-methyl-

Chemical Property:

• XLogP3: -1.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 195.08954328
• Heavy Atom Count: 14
• Complexity: 208

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)O)CC(C(=O)O)N
• Isomeric SMILES: CC1=C(C=CC(=C1)O)C[C@@H](C(=O)O)N

Technology Process of L-Tyrosine, 2-methyl-

There total 2 articles about L-Tyrosine, 2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (35186-98-2) → 2-methyl-L-tyrosine (70680-92-1,128573-13-7,2370-56-1) + D-2'-methyltyrosine (128573-13-7,2370-56-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; at 60 ℃; for 24h; under 3800 Torr;

DOI:10.1016/S0223-5234(00)01171-5

Reference yield:

2-oxo-propionic acid (127-17-3) + 3-methyl-phenol (108-39-4) → 2-methyl-L-tyrosine (70680-92-1,128573-13-7,2370-56-1)

Guidance literature:

With tyrosine phenol-lyase; ammonia; Enzymatic reaction;

DOI:10.1016/S0968-0896(00)00053-5

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-methyl-L-tyrosine (70680-92-1,128573-13-7,2370-56-1) → 2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-2-methyl-phenyl)-propionic acid (326484-99-5)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; for 40h; pH=9;

DOI:10.1016/S0223-5234(00)01171-5

upstream raw materials:

2-oxo-propionic acid

3-methyl-phenol

7-hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid

Downstream raw materials:

α-D-L-2-methyltyrosine

2-tert-butoxycarbonylamino-3-(4-tert-butoxycarbonyloxy-2-methyl-phenyl)-propionic acid