(R)-(tetrahydro-2H-pyran-2-yl)methanol

Base Information

• Chemical Name: (R)-(tetrahydro-2H-pyran-2-yl)methanol
• CAS No.: 70766-06-2
• Molecular Formula: C6H12O2
• Molecular Weight: 116.15800
• Mol file: 70766-06-2.mol

Synonyms:

Chemical Property of (R)-(tetrahydro-2H-pyran-2-yl)methanol

Chemical Property:

• PSA: 29.46000
• LogP: 0.54780

Purity/Quality:

99% ^*data from raw suppliers

(R)-2-(Hydroxymethyl)oxane 95+% ee ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(tetrahydro-2H-pyran-2-yl)methanol

There total 17 articles about (R)-(tetrahydro-2H-pyran-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(R,E)-2-(4-phenylbut-1-en-1-yl)tetrahydro-2H-pyran (1268368-68-8) → (2R)-tetrahydro-2H-pyran-2-ylmethanol (70766-06-2)

Guidance literature:

(R,E)-2-(4-phenylbut-1-en-1-yl)tetrahydro-2H-pyran; With ozone; In methanol; dichloromethane; at -78 ℃; for 0.5h;

With sodium tetrahydroborate; In methanol; dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol200203k

Reference yield: 30.0%

C26H36O3Si → (2R)-tetrahydro-2H-pyran-2-ylmethanol (70766-06-2)

Guidance literature:

C₂₆H₃₆O₃Si; With ozone; In methanol; dichloromethane; at -78 ℃; for 0.0833333h;

With sodium tetrahydroborate; In methanol; dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/acs.joc.8b00026

Reference yield:

(R)-2-[(benzyloxy)methyl]tetrahydro-2H-pyran → (2R)-tetrahydro-2H-pyran-2-ylmethanol (70766-06-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol;

upstream raw materials:

(R)-(+)-Methyl Tetrahydropyran-2-carboxylate

(-)-(S)-2-ethyltetrahydropyran

Tetrahydropyran-2-methanol

tetrahydro-(+)-(R)-2-vinylpyran

Refernces

• 1、 Setterholm, Noah A.,McDonald, Frank E.. "Stereoselective Synthesis of Pyrans from Epoxyalkenes: Dual Catalysis with Palladium and Br?nsted Acid". . p. 6259 - 6274. Retrieved 2018/05/29.
• 2、 -. "Substituted Oxopyridine Derivatives and Use Thereof in the Treatment of Cardiovascular Disorders". . . Retrieved 2016/05/02.