1'-Methyl-3-phenylspiro[isobenzofuran-1(3H),4'-piperidine]

Base Information

• Chemical Name: 1'-Methyl-3-phenylspiro[isobenzofuran-1(3H),4'-piperidine]
• CAS No.: 59142-29-9
• Molecular Formula: C19H21NO
• Molecular Weight: 279.38
• Mol file: 59142-29-9.mol

Synonyms:1,3-Dihydro-1'-methyl-3-phenylspiro[isobenzofuran-1,4'-piperidin];1,3-dihydro-1'-methyl-3-phenylspiro[isobenzofuran-1,4'piperidine];1,3-dihydro-1'-methyl-3-phenylspiro[isobenzofuran-1,4'-piperidine];

Chemical Property of 1'-Methyl-3-phenylspiro[isobenzofuran-1(3H),4'-piperidine]

Chemical Property:

• PSA: 12.47000
• LogP: 3.66500

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1'-Methyl-3-phenylspiro[isobenzofuran-1(3H),4'-piperidine]

There total 11 articles about 1'-Methyl-3-phenylspiro[isobenzofuran-1(3H),4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-hydroxy-1-methyl-piperidin-4-yl)-benzophenone (54595-77-6) + 4-hydroxy-(α-hydroxy-α-phenyl-2-tolyl)-1-methylpiperidine → 1'-methyl-3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine] (59142-29-9)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; acetic acid;

Reference yield:

1-Methyl-4-piperidone (1445-73-4) + 4-[2-(hydroxy-phenyl-methyl)-phenyl]-1-methyl-piperidin-4-ol (59142-28-8) + ammonium chloride → 1'-methyl-3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine] (59142-29-9)

Guidance literature:

With n-butyllithium; formic acid; In tetrahydrofuran; hexane;

Reference yield:

1-Methyl-4-piperidone (1445-73-4) + 4-hydroxy-4-(α-methoxy-α-phenyl-2-tolyl)-1-methylpiperidine + benzhydrol methyl ether + 1-bromo-2-[methoxy(phenyl)methyl]-benzene (59142-71-1) + (2-bromophenyl)phenylmethanol (59142-47-1) → 1'-methyl-3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine] (59142-29-9)

Guidance literature:

With hydrogenchloride; n-butyllithium; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; hexane; water;

upstream raw materials:

1-Methyl-4-piperidone

1-bromo-2-[methoxy(phenyl)methyl]-benzene

3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-carboxylic acid ethyl ester

4-[2-(hydroxy-phenyl-methyl)-phenyl]-1-methyl-piperidin-4-ol

Downstream raw materials:

3-butyl-1'-methyl-3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine]

3-ethyl-1'-methyl-3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine]

3-phenyl-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-carboxylic acid ethyl ester

1'-methyl-3-phenyl-3-propyl-3H-spiro[isobenzofuran-1,4'-piperidine]

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