1H-Pyrazole-5-carboxamide, 1-[3-cyano-4-[[(1-methylethylidene)amino]oxy]phenyl]-N-[2'-[[(1,1-dimeth ylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-3-methyl-

Base Information

Chemical Name:1H-Pyrazole-5-carboxamide, 1-[3-cyano-4-[[(1-methylethylidene)amino]oxy]phenyl]-N-[2'-[[(1,1-dimeth ylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-3-methyl-
CAS No.:709655-26-5
Molecular Formula:C31H32N6O4S
Molecular Weight:584.699
Hs Code.:

1H-Pyrazole-5-carboxamide,
1-[3-cyano-4-[[(1-methylethylidene)amino]oxy]phenyl]-N-[2'-[[(1,1-dimeth
ylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-3-methyl-

Synonyms:

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Chemical Property of 1H-Pyrazole-5-carboxamide, 1-[3-cyano-4-[[(1-methylethylidene)amino]oxy]phenyl]-N-[2'-[[(1,1-dimeth ylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-3-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-5-carboxamide, 1-[3-cyano-4-[[(1-methylethylidene)amino]oxy]phenyl]-N-[2'-[[(1,1-dimeth ylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-3-methyl-

There total 4 articles about 1H-Pyrazole-5-carboxamide, 1-[3-cyano-4-[[(1-methylethylidene)amino]oxy]phenyl]-N-[2'-[[(1,1-dimeth ylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-3-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 209959-22-8
2-(3-cyano-4-fluoro-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

: 127-06-0
acetone oxime

: 709655-26-5
N-{2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl-4-yl}-1-(3-cyano-4-isopropylideneaminooxyphenyl)-3-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: acetone oxime; With sodium t-butanolate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2-(3-cyano-4-fluoro-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1021/jm020578e

Reference yield:

: 53312-81-5
3-cyano-4-fluoroaniline

: 709655-26-5
N-{2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl-4-yl}-1-(3-cyano-4-isopropylideneaminooxyphenyl)-3-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaNO₂; HCl / 0 °C

1.2: SnCl₂

2.1: ethanol / 5 h / Heating

3.1: Me₃Al / CH₂Cl₂; hexane / 0.25 h / 20 °C

3.2: CH₂Cl₂; hexane / 18 h / 40 °C

4.1: t-BuONa / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C

4.2: dimethylformamide; tetrahydrofuran / 5 h / 20 °C

With hydrogenchloride; trimethylaluminum; sodium t-butanolate; sodium nitrite; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020578e

Reference yield:

: 161886-21-1
2-fluoro-5-hydrazinobenzonitrile

: 709655-26-5
N-{2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl-4-yl}-1-(3-cyano-4-isopropylideneaminooxyphenyl)-3-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 5 h / Heating

2.1: Me₃Al / CH₂Cl₂; hexane / 0.25 h / 20 °C

2.2: CH₂Cl₂; hexane / 18 h / 40 °C

3.1: t-BuONa / dimethylformamide; tetrahydrofuran / 0.5 h / 20 °C

3.2: dimethylformamide; tetrahydrofuran / 5 h / 20 °C

With trimethylaluminum; sodium t-butanolate; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020578e