Ethyl 4-hydroxybenzo[h]quinoline-3-carboxylate

Base Information

• Chemical Name: Ethyl 4-hydroxybenzo[h]quinoline-3-carboxylate
• CAS No.: 71083-13-1
• Molecular Formula: C16H13NO3
• Molecular Weight: 267.284
• Hs Code.: 2933990090
• Mol file: 71083-13-1.mol

Synonyms:Ethyl benzo[h]-4-chinolin-3-carboxylat;ethyl 4-oxo-1,4-dihydrobenzo[h]quinoline-3-carboxylate;

Chemical Property of Ethyl 4-hydroxybenzo[h]quinoline-3-carboxylate

Chemical Property:

• PSA: 59.16000
• LogP: 2.85800

Purity/Quality:

99% ^*data from raw suppliers

Ethyl4-hydroxybenzo[h]quinoline-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-hydroxybenzo[h]quinoline-3-carboxylate

There total 9 articles about Ethyl 4-hydroxybenzo[h]quinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-[(naphthalen-1-ylamino)methylidene]malonic acid diethyl ester (131775-94-5) → ethyl 4-oxo-1,4-dihydrobenzoquinoline-3-carboxylate (71083-13-1)

Guidance literature:

In diphenylether; at 240 - 250 ℃;

DOI:10.1016/j.bmcl.2009.02.016

Reference yield: 68.0%

→ ethyl 4-oxo-1,4-dihydrobenzoquinoline-3-carboxylate (71083-13-1)

Guidance literature:

at 130 ℃; for 24h;

In diphenylether; for 0.75h; Reflux;

Reference yield: 48.0%

2-[(naphthalen-1-ylamino)methylidene]malonic acid diethyl ester (131775-94-5) → benzo[h]quinolin-4(1H)-one (65504-13-4,23443-09-6) + ethyl 4-oxo-1,4-dihydrobenzoquinoline-3-carboxylate (71083-13-1)

Guidance literature:

In tetrahydrofuran; at 390 ℃; under 75007.5 Torr;

DOI:10.1021/acs.joc.6b02520

upstream raw materials:

2-[(naphthalen-1-ylamino)methylidene]malonic acid diethyl ester

1-amino-naphthalene

diethyl 2-ethoxymethylenemalonate

Downstream raw materials:

4-hydroxy-benzo[h]quinoline-3-carboxylic acid

3-carbethoxy-4-chlorobenzo(h)quinoline

4-hydroxybenzo[h]quinoline

4-oxo-1,4-dihydrobenzo[h]quinoline-3-carboxylic acid

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