1H-Imidazole, 4,5-dihydro-4,4-dimethyl-1-[(4-methylphenyl)sulfonyl]-

Base Information

• Chemical Name: 1H-Imidazole, 4,5-dihydro-4,4-dimethyl-1-[(4-methylphenyl)sulfonyl]-
• CAS No.: 71254-89-2
• Molecular Formula: C12H16N2O2S
• Molecular Weight: 252.337
• DSSTox Substance ID: DTXSID80453116
• Wikidata: Q82274134

Synonyms:71254-89-2;1H-Imidazole, 4,5-dihydro-4,4-dimethyl-1-[(4-methylphenyl)sulfonyl]-;DTXSID80453116;4,4-Dimethyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-imidazole

Chemical Property of 1H-Imidazole, 4,5-dihydro-4,4-dimethyl-1-[(4-methylphenyl)sulfonyl]-

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 252.09324893
• Heavy Atom Count: 17
• Complexity: 401

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)N2CC(N=C2)(C)C

Technology Process of 1H-Imidazole, 4,5-dihydro-4,4-dimethyl-1-[(4-methylphenyl)sulfonyl]-

There total 2 articles about 1H-Imidazole, 4,5-dihydro-4,4-dimethyl-1-[(4-methylphenyl)sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4,4-dimethyl-2-imidazoline (2305-59-1) + p-toluenesulfonyl chloride (98-59-9) → 1-p-toluenesulfonyl-4,4-dimethyl-Δ2-imidazoline (71254-89-2)

Guidance literature:

With triethylamine; In dichloromethane; 0 deg C, then warming to RT, 1 h;

DOI:10.1016/S0040-4020(01)90903-2

Reference yield:

→ 1-p-toluenesulfonyl-4,4-dimethyl-Δ2-imidazoline (71254-89-2)

Guidance literature:

Imidazolidin (2), p-Toluolsulfonsaeurechlorid;

DOI:10.1039/c39790000117

Reference yield: 93.0%

1-p-toluenesulfonyl-4,4-dimethyl-Δ2-imidazoline (71254-89-2) → (5R,6R,5'S)-6-(2',2'-dimethyl-5'-phenyl-1'-aza-3'-oxacyclopentyl)-2,2-dimethyl-4-p-toluenesulfonyl-1,4-diazabicyclo<3.2.0>heptan-7-one + (5S,6S,5'S)-6-(2',2'-dimethyl-5'-phenyl-1'-aza-3'-oxacyclopentyl)-2,2-dimethyl-4-p-toluenesulfonyl-1,4-diazabicyclo<3.2.0>heptan-7-one (153462-94-3)

Guidance literature:

In diethyl ether; for 16h; Yields of byproduct given; Irradiation;

DOI:10.1016/S0040-4020(01)87268-9

upstream raw materials:

4,4-dimethyl-2-imidazoline

p-toluenesulfonyl chloride

Downstream raw materials:

1-tosyl-3,4,4-trimethyl-Δ²-imidazolinium iodide

(5S,6S,5'S)-6-(2',2'-dimethyl-5'-phenyl-1'-aza-3'-oxacyclopentyl)-2,2-dimethyl-4-p-toluenesulfonyl-1,4-diazabicyclo<3.2.0>heptan-7-one

(5S,6S)-6-amino-2,2-dimethyl-4-p-toluenesulfonyl-1,4-diazabicyclo<3.2.0>heptan-7-one

(5S,6S)-6-((S)-2-Hydroxy-1-phenyl-ethylamino)-2,2-dimethyl-4-(toluene-4-sulfonyl)-1,4-diaza-bicyclo[3.2.0]heptan-7-one

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